Dnajb5 MGI Mouse Gene Detail - MGI:1930018 - DnaJ heat shock protein family (Hsp40) member B5

Symbol

Dnajb5
Name

DnaJ heat shock protein family (Hsp40) member B5
Synonyms

1110058L06Rik, Hsc40, Hsp40-3

Feature Type

protein coding gene
IDs

MGI:1930018
NCBI Gene: 56323
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr4:42949866-42959425 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 22.93 cM, cytoband B1
Mapping Data

3 experiments

SNPs within 2kb

268 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1930018	protein coding gene	Chr4:42949814-42959425 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028194	protein coding gene	Chr4:41022744-41032921 (+)
A/J	MGP_AJ_G0028150	protein coding gene	Chr4:39588312-39597177 (+)
AKR/J	MGP_AKRJ_G0028102	protein coding gene	Chr4:40484907-40493732 (+)
BALB/cJ	MGP_BALBcJ_G0028170	protein coding gene	Chr4:39675193-39684363 (+)
C3H/HeJ	MGP_C3HHeJ_G0027892	protein coding gene	Chr4:41113732-41122597 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028611	protein coding gene	Chr4:42555897-42564781 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025923	protein coding gene	Chr4:37050272-37060336 (+)
CAST/EiJ	MGP_CASTEiJ_G0027332	protein coding gene	Chr4:40584617-40596725 (+)
CBA/J	MGP_CBAJ_G0027858	protein coding gene	Chr4:43891030-43899908 (+)
DBA/2J	MGP_DBA2J_G0028007	protein coding gene	Chr4:39497997-39507267 (+)
FVB/NJ	MGP_FVBNJ_G0027974	protein coding gene	Chr4:38725144-38733995 (+)
LP/J	MGP_LPJ_G0028106	protein coding gene	Chr4:41095653-41104490 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027998	protein coding gene	Chr4:47149210-47158037 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028647	protein coding gene	Chr4:40683320-40692165 (+)
PWK/PhJ	MGP_PWKPhJ_G0027058	protein coding gene	Chr4:39536381-39545639 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026884	protein coding gene	Chr4:40236504-40246781 (+)
WSB/EiJ	MGP_WSBEiJ_G0027412	protein coding gene	Chr4:40589820-40600250 (+)

Human Ortholog

DNAJB5, DnaJ heat shock protein family (Hsp40) member B5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJB5, DnaJ heat shock protein family (Hsp40) member B5
Synonyms

Hsc40
Links

HGNC:14887

NCBI Gene ID: 25822

neXtProt AC: NX_O75953

UniProt: O75953
Chr Location

9p13.3; chr9:34989641-34998900 (+) GRCh38

MGI Vertebrate Homology

Dnajb5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DNAJB5
Gene Tree

Dnajb5

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically and radiation induced

1
Endonuclease-mediated

1
Gene trapped

6
Genomic Mutations

1 involving Dnajb5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

963
Tissues

58
cDNA Data

25
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnajb5

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All Sequences

77
RefSeq

26
UniProt

4
CCDS

CCDS18084.1, CCDS89731.1

Ensembl

ENSMUSG00000036052 (Evidence)
NCBI Gene

56323

			Length	Strain/Species	Flank
genomic	56323	NCBI Gene Model \| MGI Sequence Detail	9560	C57BL/6J	± kb
transcript	NM_001355438	RefSeq \| MGI Sequence Detail	3535	C57BL/6
polypeptide	O89114	UniProt \| EBI \| MGI Sequence Detail	348	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000031646 DnaJ homolog subfamily B member 5

(term hierarchy)
InterPro Domains

IPR002939 Chaperone DnaJ, C-terminal

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR018253 DnaJ domain, conserved site

IPR051339 DnaJ homolog subfamily B

IPR008971 HSP40/DnaJ peptide-binding
GlyGen

O89114 1 site, 1 O-linked glycan (1 site)

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All nucleic 25

cDNA 25

Microarray probesets 5

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MGI:1916009, MGI:2140298

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 8
Earliest

J:58146 Chen MS, et al., Hsc40, a new member of the hsp40 family, exhibits similar expression profile to that of hsc70 in mammalian cells. Gene. 1999 Oct 1;238(2):333-41
Latest

J:346667 San Gil R, et al., A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. Nat Commun. 2024 Feb 19;15(1):1508

TSS for Dnajb5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36908	Chr4:42949861-42949923 (+)	26 bp
Tssr36909	Chr4:42950369-42950445 (+)	541 bp
Tssr36910	Chr4:42950451-42950475 (+)	597 bp
Tssr36911	Chr4:42950481-42950492 (+)	621 bp
Tssr36912	Chr4:42952772-42952780 (+)	2,910 bp
Tssr36913	Chr4:42952794-42952805 (+)	2,934 bp
Tssr36914	Chr4:42952808-42952822 (+)	2,949 bp
Tssr1154	Chr4:42952825-42952828 (+)	2,961 bp
Tssr36915	Chr4:42957422-42957432 (+)	7,561 bp
Tssr36916	Chr4:42957458-42957466 (+)	7,596 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24