Mcm3ap MGI Mouse Gene Detail - MGI:1930089 - minichromosome maintenance complex component 3 associated protein

Symbol

Mcm3ap
Name

minichromosome maintenance complex component 3 associated protein
Synonyms

GANP, mKIAA0572

Feature Type

protein coding gene
IDs

MGI:1930089
NCBI Gene: 54387
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:76304761-76351691 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 38.88 cM
Mapping Data

2 experiments

SNPs within 2kb

1218 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1930089	protein coding gene	Chr10:76304736-76351693 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017384	protein coding gene	Chr10:76712837-76768178 (+)
A/J	MGP_AJ_G0017361	protein coding gene	Chr10:74059542-74114520 (+)
AKR/J	MGP_AKRJ_G0017322	protein coding gene	Chr10:76060132-76111811 (+)
BALB/cJ	MGP_BALBcJ_G0017321	protein coding gene	Chr10:74267053-74317987 (+)
C3H/HeJ	MGP_C3HHeJ_G0017145	protein coding gene	Chr10:76136516-76192324 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017779	protein coding gene	Chr10:79423099-79473582 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015469	protein coding gene	Chr10:70515063-70561932 (+)
CAST/EiJ	MGP_CASTEiJ_G0016715	protein coding gene	Chr10:76454386-76504750 (+)
CBA/J	MGP_CBAJ_G0017117	protein coding gene	Chr10:82527024-82584579 (+)
DBA/2J	MGP_DBA2J_G0017222	protein coding gene	Chr10:73368827-73416147 (+)
FVB/NJ	MGP_FVBNJ_G0017214	protein coding gene	Chr10:72525760-72573770 (+)
LP/J	MGP_LPJ_G0017295	protein coding gene	Chr10:77209271-77255615 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017243	protein coding gene	Chr10:84587593-84640108 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017818	protein coding gene	Chr10:76117316-76171383 (+)
PWK/PhJ	MGP_PWKPhJ_G0016499	protein coding gene	Chr10:73212884-73260456 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016282	protein coding gene	Chr10:75347995-75398298 (+)
WSB/EiJ	MGP_WSBEiJ_G0016778	protein coding gene	Chr10:76095817-76149044 (+)

Human Ortholog

MCM3AP, minichromosome maintenance complex component 3 associated protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MCM3AP, minichromosome maintenance complex component 3 associated protein
Synonyms

GANP, MAP80, PNRIID, SAC3
Links

HGNC:6946

NCBI Gene ID: 8888

neXtProt AC: NX_O60318

UniProt: O60318
Chr Location

21q22.3; chr21:46235133-46286297 (-) GRCh38

MGI Vertebrate Homology

Mcm3ap stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MCM3AP
Gene Tree

Mcm3ap

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References

2 with disease annotations

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

10
Targeted

6
Genomic Mutations

5 involving Mcm3ap
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

78 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele die by E12.

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All GO Annotations

50
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

804
Tissues

74
cDNA Data

122
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mcm3ap

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All Sequences

55
RefSeq

6
UniProt

7
CCDS

CCDS23947.1

Ensembl

ENSMUSG00000001150 (Evidence)
NCBI Gene

54387

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001150	Ensembl Gene Model \| MGI Sequence Detail	46931	C57BL/6J	± kb
transcript	ENSMUST00000170795	Ensembl \| MGI Sequence Detail	6427	Not Applicable
polypeptide	ENSMUSP00000125960	Ensembl \| MGI Sequence Detail	1971	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000010244 germinal-center associated nuclear protein

(term hierarchy)
EC

2.3.1.48
InterPro Domains

IPR031910 Germinal-centre associated nuclear protein, CID domain

IPR031907 Germinal-centre associated nuclear protein, MCM3AP domain

IPR031908 Germinal-centre associated nuclear protein, nucleoporin homology domain

IPR034265 MCM3AP, RNA recognition motif

IPR000717 Proteasome component (PCI) domain

IPR035979 RNA-binding domain superfamily

IPR045107 SAC3/GANP/THP3

IPR005062 SAC3/GANP/THP3, conserved domain
GlyGen

Q9WUU9 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)

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All nucleic 126

Genomic 1

cDNA 122

Primer pair 2

Other 1

Microarray probesets 3

Summaries

All 81

Developmental Gene Expression 5

Diseases 2

Gene Ontology 9

Phenotypes 44
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599

TSS for Mcm3ap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94181	Chr10:76304700-76304827 (+)	3 bp
Tssr94182	Chr10:76304910-76304920 (+)	154 bp
Tssr94183	Chr10:76316866-76316876 (+)	12,110 bp
Tssr94184	Chr10:76316884-76316928 (+)	12,145 bp
Tssr94185	Chr10:76316935-76316961 (+)	12,187 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24