Pmaip1 MGI Mouse Gene Detail - MGI:1930146 - phorbol-12-myristate-13-acetate-induced protein 1

Symbol

Pmaip1
Name

phorbol-12-myristate-13-acetate-induced protein 1
Synonyms

Noxa

Feature Type

protein coding gene
IDs

MGI:1930146
NCBI Gene: 58801
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr18:66591675-66598629 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 39.52 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

307 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1930146	protein coding gene	Chr18:66591604-66598636 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024517	protein coding gene	Chr18:66689358-66696304 (+)
A/J	MGP_AJ_G0024484	protein coding gene	Chr18:63767382-63774328 (+)
AKR/J	MGP_AKRJ_G0024454	protein coding gene	Chr18:65608076-65615022 (+)
BALB/cJ	MGP_BALBcJ_G0024483	protein coding gene	Chr18:63918630-63925576 (+)
C3H/HeJ	MGP_C3HHeJ_G0024251	protein coding gene	Chr18:65792698-65799644 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024930	protein coding gene	Chr18:68442123-68449069 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022361	protein coding gene	Chr18:63192852-63199912 (+)
CAST/EiJ	MGP_CASTEiJ_G0023724	protein coding gene	Chr18:65803745-65810721 (+)
CBA/J	MGP_CBAJ_G0024221	protein coding gene	Chr18:70765154-70772100 (+)
DBA/2J	MGP_DBA2J_G0024351	protein coding gene	Chr18:63437325-63444271 (+)
FVB/NJ	MGP_FVBNJ_G0024317	protein coding gene	Chr18:62807488-62814434 (+)
LP/J	MGP_LPJ_G0024435	protein coding gene	Chr18:66535934-66542880 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024346	protein coding gene	Chr18:72075683-72082629 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024977	protein coding gene	Chr18:65810123-65817069 (+)
PWK/PhJ	MGP_PWKPhJ_G0023467	protein coding gene	Chr18:63697657-63704618 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023272	protein coding gene	Chr18:65968926-65975914 (+)
WSB/EiJ	MGP_WSBEiJ_G0023788	protein coding gene	Chr18:65656049-65663889 (+)

Human Ortholog

PMAIP1, phorbol-12-myristate-13-acetate-induced protein 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PMAIP1, phorbol-12-myristate-13-acetate-induced protein 1
Synonyms

APR, NOXA
Links

HGNC:9108

NCBI Gene ID: 5366

neXtProt AC: NX_Q13794

UniProt: Q13794
Chr Location

18q21.32; chr18:59899996-59904305 (+) GRCh38

MGI Vertebrate Homology

Pmaip1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PMAIP1
Gene Tree

Pmaip1

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Phenotype Summary

8 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
50 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Targeted

5
Incidental Mutations

CvDC
Find Mice (IMSR)

12 strains or lines available

Though inactivation of this gene results in apoptotic abnormalities, homozygous null mice develop normally and show no evidence of tumorigenesis.

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All GO Annotations

47
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

803
Tissues

42
cDNA Data

30
Literature Summary

41

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

2
UniProt

3
CCDS

CCDS29315.1

Ensembl

ENSMUSG00000024521 (Evidence)
NCBI Gene

58801

			Length	Strain/Species	Flank
genomic	58801	NCBI Gene Model \| MGI Sequence Detail	6955	C57BL/6J	± kb
transcript	NM_021451	RefSeq \| MGI Sequence Detail	2654	C57BL/6
polypeptide	Q9JM54	UniProt \| EBI \| MGI Sequence Detail	103	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012900 phorbol-12-myristate-13-acetate-induced protein 1

(term hierarchy)
PDB

2JM6, 2NLA, 2ROD
InterPro Domains

IPR024140 Phorbol-12-myristate-13-acetate-induced protein 1

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All nucleic 41

cDNA 30

Primer pair 9

Other 2

Microarray probesets 3

Summaries

All 139

Developmental Gene Expression 41

Gene Ontology 19

Phenotypes 50
Earliest

J:62057 Oda E, et al., Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science. 2000 May 12;288(5468):1053-8
Latest

J:352165 Lin Y, et al., Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development. Dev Dyn. 2024 Jul;253(7):635-647

TSS for Pmaip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151705	Chr18:66591658-66591675 (+)	-8 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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