Popdc2 MGI Mouse Gene Detail - MGI:1930150 - popeye domain containing 2

Symbol

Popdc2
Name

popeye domain containing 2
Synonyms

Pop2

Feature Type

protein coding gene
IDs

MGI:1930150
NCBI Gene: 64082
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr16:38182571-38198578 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 26.79 cM
Mapping Data

2 experiments

SNPs within 2kb

470 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1930150	protein coding gene	Chr16:38182523-38198578 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022813	protein coding gene	Chr16:36887734-36903780 (+)
A/J	MGP_AJ_G0022778	protein coding gene	Chr16:35058940-35073238 (+)
AKR/J	MGP_AKRJ_G0022750	protein coding gene	Chr16:36390408-36406251 (+)
BALB/cJ	MGP_BALBcJ_G0022779	protein coding gene	Chr16:35178062-35192419 (+)
C3H/HeJ	MGP_C3HHeJ_G0022543	protein coding gene	Chr16:36494576-36508955 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023226	protein coding gene	Chr16:37726941-37742949 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020741	protein coding gene	Chr16:35434135-35449426 (+)
CAST/EiJ	MGP_CASTEiJ_G0022069	protein coding gene	Chr16:36650121-36665662 (+)
CBA/J	MGP_CBAJ_G0022514	protein coding gene	Chr16:39387624-39403131 (+)
DBA/2J	MGP_DBA2J_G0022646	protein coding gene	Chr16:34940739-34955096 (+)
FVB/NJ	MGP_FVBNJ_G0022621	protein coding gene	Chr16:34971315-34986357 (+)
LP/J	MGP_LPJ_G0022714	protein coding gene	Chr16:36569301-36585763 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022640	protein coding gene	Chr16:38505134-38521480 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023241	protein coding gene	Chr16:36352844-36367195 (+)
PWK/PhJ	MGP_PWKPhJ_G0021809	protein coding gene	Chr16:35355111-35371434 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021640	protein coding gene	Chr16:36249386-36264710 (+)
WSB/EiJ	MGP_WSBEiJ_G0022113	protein coding gene	Chr16:36422734-36439983 (+)

Human Ortholog

POPDC2, popeye domain cAMP effector 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

POPDC2, popeye domain cAMP effector 2
Synonyms

POP2
Links

HGNC:17648

NCBI Gene ID: 64091

neXtProt AC: NX_Q9HBU9

UniProt: Q9HBU9
Chr Location

3q13.33; chr3:119636457-119665324 (-) GRCh38

MGI Vertebrate Homology

Popdc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: POPDC2
Gene Tree

Popdc2

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Gene trapped

5
Targeted

4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit sinus brachycardia in response to physical or mental stress and catecholamines with a compact sinoatrial node.

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1010
Tissues

137
cDNA Data

30
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA POPDC2

Xenbase popdc2

ZFIN popdc2

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All Sequences

49
RefSeq

10
UniProt

2
CCDS

CCDS37342.1, CCDS37343.1

Ensembl

ENSMUSG00000022803 (Evidence)
NCBI Gene

64082

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022803	Ensembl Gene Model \| MGI Sequence Detail	16008	C57BL/6J	± kb
transcript	ENSMUST00000023494	Ensembl \| MGI Sequence Detail	2169	Not Applicable
polypeptide	ENSMUSP00000023494	Ensembl \| MGI Sequence Detail	371	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013028 popeye domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR018490 Cyclic nucleotide-binding domain superfamily

IPR006916 Popeye protein

IPR014710 RmlC-like jelly roll fold
GlyGen

Q9ES82 2 sites

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All nucleic 36

cDNA 30

Primer pair 5

Other 1

Microarray probesets 3

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MGI:2146588

Summaries

All 31

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 7
Earliest

J:63597 Andree B, et al., Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart. Dev Biol. 2000 Jul 15;223(2):371-82
Latest

J:352048 Swan AH, et al., Differential effects of mutations of POPDC proteins on heteromeric interaction and membrane trafficking. Acta Neuropathol Commun. 2023 Jan 9;11(1):4

TSS for Popdc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138377	Chr16:38182526-38182540 (+)	-38 bp
Tssr138378	Chr16:38182541-38182558 (+)	-21 bp
Tssr138379	Chr16:38182567-38182592 (+)	9 bp
Tssr138380	Chr16:38182596-38182613 (+)	34 bp
Tssr138381	Chr16:38192335-38192368 (+)	9,781 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24