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Maged1 Gene Detail
Summary
  • Symbol
    Maged1
  • Name
    MAGE family member D1
  • Synonyms
    2810433C11Rik, 5430405L04Rik, Dlxin-1, DXBwg1492e, MAGE-D1, Nrage
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930187
    NCBI Gene: 94275
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:93579080-93585631 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 41.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930187
 protein coding gene ChrX:93579080-93585749 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035912
 protein coding gene ChrX:90958381-90965050 (-)
A/J MGP_AJ_G0035898
 protein coding gene ChrX:91040587-91047311 (-)
AKR/J MGP_AKRJ_G0035815
 protein coding gene ChrX:93445943-93452617 (-)
BALB/cJ MGP_BALBcJ_G0035882
 protein coding gene ChrX:89759886-89766573 (-)
C3H/HeJ MGP_C3HHeJ_G0035591
 protein coding gene ChrX:91314078-91320750 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036411
 protein coding gene ChrX:93734744-93741413 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033238
 protein coding gene ChrX:89193391-89200063 (-)
CAST/EiJ MGP_CASTEiJ_G0034876
 protein coding gene ChrX:75974426-75981357 (-)
CBA/J MGP_CBAJ_G0035565
 protein coding gene ChrX:96426022-96432694 (-)
DBA/2J MGP_DBA2J_G0035721
 protein coding gene ChrX:90271993-90278662 (-)
FVB/NJ MGP_FVBNJ_G0035660
 protein coding gene ChrX:89674900-89681638 (-)
LP/J MGP_LPJ_G0035810
 protein coding gene ChrX:91766056-91772725 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035694
 protein coding gene ChrX:100754384-100761053 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036438
 protein coding gene ChrX:90655087-90661759 (-)
PWK/PhJ MGP_PWKPhJ_G0034575
 protein coding gene ChrX:73742712-73749378 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034405
 protein coding gene ChrX:76838043-76844720 (-)
WSB/EiJ MGP_WSBEiJ_G0035017
 protein coding gene ChrX:89463842-89470515 (-)



Homology
more
  • Human Ortholog
    MAGED1, MAGE family member D1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAGED1, MAGE family member D1
  • Synonyms
    DLXIN-1, NRAGE
  • Links
    NCBI Gene ID: 9500
    neXtProt AC: NX_Q9Y5V3
    UniProt: Q9Y5V3

  • Chr Location
    Xp11.22; chrX:51803007-51902354 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 4 alleles in 5 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display defects in apoptotic signaling affecting hair cycling and neuronal physiology. Mice homozygous for a different knock-out allele exhibit hypoactivity, decreased exploration, social withdrawal, anhedonia, behavioral despair andaltered serotonin levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1280
  • Tissues
    167
  • cDNA Data
    635
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 94275 NCBI Gene Model | MGI Sequence Detail 6552 C57BL/6J ±  kb
    transcript NR_157578 RefSeq | MGI Sequence Detail 2921 ZRU/MplStud  
    polypeptide Q9QYH6 UniProt | EBI | MGI Sequence Detail 775 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 646
      cDNA 635
      Primer pair 5
      Other 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35682, MGI:107217, MGI:1917220, MGI:1922987
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 27
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory