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Cyp3a25 Gene Detail
Summary
  • Symbol
    Cyp3a25
  • Name
    cytochrome P450, family 3, subfamily a, polypeptide 25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930638
    NCBI Gene: 56388
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:145914004-145946428 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 85.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1418 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930638
 protein coding gene Chr5:145914002-145946454 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030372
 protein coding gene Chr5:151447544-151531535 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0030271
 protein coding gene Chr5:149485544-149551011 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0030067
 protein coding gene Chr5:150366720-150410822 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0028019
 protein coding gene Chr5:138790680-138797302 (+)
CAST/EiJ MGP_CASTEiJ_G0029469
 protein coding gene Chr5:150016890-150056856 (+)
CBA/J MGP_CBAJ_G0030039
 protein coding gene Chr5:163499571-163565711 (-)
DBA/2J MGP_DBA2J_G0030189
 protein coding gene Chr5:144713932-144720566 (-)
FVB/NJ MGP_FVBNJ_G0030142
 protein coding gene Chr5:144056356-144114552 (+)
LP/J MGP_LPJ_G0030277
 protein coding gene Chr5:152129226-152222861 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0029184
 protein coding gene Chr5:143894317-143930333 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029020
 protein coding gene Chr5:146827749-146869364 (-)
WSB/EiJ MGP_WSBEiJ_G0029547
 protein coding gene Chr5:150336345-150388770 (+)



Homology
more
  • Human Ortholog
    CYP3A43, cytochrome P450 family 3 subfamily A member 43
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP3A43, cytochrome P450 family 3 subfamily A member 43
  • Links
    NCBI Gene ID: 64816
    neXtProt AC: NX_Q9HB55
    UniProt: Q9HB55

  • Chr Location
    7q22.1; chr7:99828013-99866093 (+)  GRCh38
  • Human Ortholog
    CYP3A7, cytochrome P450 family 3 subfamily A member 7
  • Synonyms
    CP37, CYPIIIA7, P-450111A7, P-450(HFL33), P450-HFLA, P450HLp2
  • Links
    NCBI Gene ID: 1551
    neXtProt AC: NX_P24462
    UniProt: P24462

  • Chr Location
    7q22.1; chr7:99705036-99735196 (-)  GRCh38
  • Human Ortholog
    CYP3A7-CYP3A51P, CYP3A7-CYP3A51P readthrough
  • Synonyms
    CYP3A7, CYP3A7.1L, CYP3A7-3AP1, CYP3A7-CYP3AP1, CYPIIIA7
  • Links
    NCBI Gene ID: 100861540
    neXtProt AC: NX_P24462

  • Chr Location
    7q22.1; chr7:99684677-99735196 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human CYP3A4,CYP3A5 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    106
  • cDNA Data
    5
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029630 Ensembl Gene Model | MGI Sequence Detail 32425 C57BL/6J ±  kb
transcript ENSMUST00000068317 Ensembl | MGI Sequence Detail 2000 Not Applicable  
polypeptide ENSMUSP00000065585 Ensembl | MGI Sequence Detail 503 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    Genomic 1
    cDNA 5
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140847
References
more
  • Summaries
    All 47
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 19
  • Earliest
    J:65712 Dai D, et al., Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase. J Biochem Mol Toxicol. 2001;15(2):90-9
  • Latest
    J:345093 Heintz MM, et al., Human CYP2B6 produces oxylipins from polyunsaturated fatty acids and reduces diet-induced obesity. PLoS One. 2022;17(12):e0277053
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory