Spz1 MGI Mouse Gene Detail - MGI:1930801 - spermatogenic leucine zipper 1

Symbol

Spz1
Name

spermatogenic leucine zipper 1
Synonyms

1700027M20Rik

Feature Type

protein coding gene
IDs

MGI:1930801
NCBI Gene: 79401
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:92711144-92712680 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 47.75 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

130 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1930801	protein coding gene	Chr13:92711139-92712740 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020818	protein coding gene	Chr13:93890199-93891800 (-)
A/J	MGP_AJ_G0020772	protein coding gene	Chr13:90417301-90418902 (-)
AKR/J	MGP_AKRJ_G0020745	protein coding gene	Chr13:93148304-93149905 (-)
BALB/cJ	MGP_BALBcJ_G0020768	protein coding gene	Chr13:91054149-91055750 (-)
C3H/HeJ	MGP_C3HHeJ_G0020562	protein coding gene	Chr13:92867371-92868972 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021205	protein coding gene	Chr13:96741663-96743264 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018772	protein coding gene	Chr13:86343940-86345539 (-)
CAST/EiJ	MGP_CASTEiJ_G0020081	protein coding gene	Chr13:92121106-92122707 (-)
CBA/J	MGP_CBAJ_G0020521	protein coding gene	Chr13:100599244-100600845 (-)
DBA/2J	MGP_DBA2J_G0020646	protein coding gene	Chr13:90175406-90177007 (-)
FVB/NJ	MGP_FVBNJ_G0020626	protein coding gene	Chr13:88996280-88997881 (-)
LP/J	MGP_LPJ_G0020719	protein coding gene	Chr13:94010097-94011698 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020655	protein coding gene	Chr13:101083701-101085302 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021245	protein coding gene	Chr13:92554700-92556301 (-)
PWK/PhJ	MGP_PWKPhJ_G0019833	protein coding gene	Chr13:88920054-88921655 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019657	protein coding gene	Chr13:88816170-88817786 (-)
WSB/EiJ	MGP_WSBEiJ_G0020138	protein coding gene	Chr13:93037941-93039542 (-)

Human Ortholog

SPZ1, spermatogenic leucine zipper 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPZ1, spermatogenic leucine zipper 1
Synonyms

CILD38, NYD-TSP1, PPP1R148
Links

HGNC:30721

NCBI Gene ID: 84654

neXtProt AC: NX_Q9BXG8

UniProt: Q9BXG8
Chr Location

5q14.1; chr5:80319625-80321842 (+) GRCh38

MGI Vertebrate Homology

Spz1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SPZ1
Gene Tree

Spz1

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

3
Genomic Mutations

1 involving Spz1
Incidental Mutations

APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a null allele exhibit normal fertility.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

768
Tissues

39
cDNA Data

41
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS26683.1

Ensembl

ENSMUSG00000046957 (Evidence)
NCBI Gene

79401

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046957	Ensembl Gene Model \| MGI Sequence Detail	1537	C57BL/6J	± kb
transcript	ENSMUST00000050658	Ensembl \| MGI Sequence Detail	1537	Not Applicable
polypeptide	ENSMUSP00000054083	Ensembl \| MGI Sequence Detail	378	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015600 spermatogenic leucine zipper protein 1

(term hierarchy)
InterPro Domains

IPR042961 Spermatogenic leucine zipper protein 1

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All nucleic 41

cDNA 41

Microarray probesets 4

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MGI:1920508, MGI:2145233

Summaries

All 37

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 8
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:348447 Nguyen TTT, et al., Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. Frontiers in Cell and Developmental Biology. 2024;12

TSS for Spz1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr4139	Chr13:92712732-92712739 (-)	-56 bp
Tssr123438	Chr13:92712673-92712708 (-)	-11 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24