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Slurp1 Gene Detail
Summary
  • Symbol
    Slurp1
  • Name
    secreted Ly6/Plaur domain containing 1
  • Synonyms
    1110021N19Rik, ARS component B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930923
    NCBI Gene: 57277
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:74598493-74599872 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 34.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    154 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930923
 protein coding gene Chr15:74596167-74599883 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021933
 protein coding gene Chr15:74506776-74510572 (-)
A/J MGP_AJ_G0021892
 protein coding gene Chr15:71848209-71851925 (-)
AKR/J MGP_AKRJ_G0021874
 protein coding gene Chr15:73688787-73692503 (-)
BALB/cJ MGP_BALBcJ_G0021899
 protein coding gene Chr15:71855804-71859520 (-)
C3H/HeJ MGP_C3HHeJ_G0021672
 protein coding gene Chr15:73841850-73845566 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022339
 protein coding gene Chr15:77324044-77327760 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019875
 protein coding gene Chr15:68260333-68264040 (-)
CAST/EiJ MGP_CASTEiJ_G0021191
 protein coding gene Chr15:74662963-74666760 (-)
CBA/J MGP_CBAJ_G0021638
 protein coding gene Chr15:79856687-79860403 (-)
DBA/2J MGP_DBA2J_G0021763
 protein coding gene Chr15:71446559-71450275 (-)
FVB/NJ MGP_FVBNJ_G0021745
 protein coding gene Chr15:70489501-70493217 (-)
LP/J MGP_LPJ_G0021835
 protein coding gene Chr15:74566078-74569794 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021768
 protein coding gene Chr15:85172236-85175948 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022360
 protein coding gene Chr15:74076711-74080423 (-)
PWK/PhJ MGP_PWKPhJ_G0020932
 protein coding gene Chr15:71552269-71556067 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020773
 protein coding gene Chr15:73965717-73969420 (-)
WSB/EiJ MGP_WSBEiJ_G0021243
 protein coding gene Chr15:74087956-74091668 (-)



Homology
more
  • Human Ortholog
    SLURP1, secreted LY6/PLAUR domain containing 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLURP1, secreted LY6/PLAUR domain containing 1
  • Synonyms
    ANUP, ARS, ArsB, LY6LS, LY6-MT, MDM
  • Links
    NCBI Gene ID: 57152
    neXtProt AC: NX_P55000
    UniProt: P55000

  • Chr Location
    8q24.3; chr8:142740949-142742406 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slurp1 mouse models; 2 with human SLURP1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice develop palmoplantar keratoderma, decreased body weight, and neuromuscular and metabolic phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    7
  • cDNA Data
    6
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57277 NCBI Gene Model | MGI Sequence Detail 1380 C57BL/6J ±  kb
    transcript NM_020519 RefSeq | MGI Sequence Detail 531 C57BL/6  
    polypeptide Q9Z0K7 UniProt | EBI | MGI Sequence Detail 110 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915863, MGI:2145993
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 6
      Phenotypes 35
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:355501 Weinberg RL, et al., Pain Hypersensitivity in SLURP1 and SLURP2 Knock-out Mouse Models of Hereditary Palmoplantar Keratoderma. J Neurosci. 2024 Jul 10;44(28)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory