Gpr180 MGI Mouse Gene Detail - MGI:1930949 - G protein-coupled receptor 180

Symbol

Gpr180
Name

G protein-coupled receptor 180
Synonyms

E130016I23Rik, ITR

Feature Type

protein coding gene
IDs

MGI:1930949
NCBI Gene: 58245
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr14:118374570-118400673 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 61.78 cM, cytoband E4
Mapping Data

2 experiments

SNPs within 2kb

1007 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1930949	protein coding gene	Chr14:118374513-118401644 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021648	protein coding gene	Chr14:115702070-115730039 (+)
A/J	MGP_AJ_G0021607	protein coding gene	Chr14:111295735-111323371 (+)
AKR/J	MGP_AKRJ_G0021583	protein coding gene	Chr14:114911578-114938835 (+)
BALB/cJ	MGP_BALBcJ_G0021613	protein coding gene	Chr14:111839864-111865622 (+)
C3H/HeJ	MGP_C3HHeJ_G0021391	protein coding gene	Chr14:114788824-114814530 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022053	protein coding gene	Chr14:120207128-120234577 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019592	protein coding gene	Chr14:107367992-107394159 (+)
CAST/EiJ	MGP_CASTEiJ_G0020907	protein coding gene	Chr14:112619217-112647875 (+)
CBA/J	MGP_CBAJ_G0021359	protein coding gene	Chr14:124809900-124840795 (+)
DBA/2J	MGP_DBA2J_G0021482	protein coding gene	Chr14:111220817-111246673 (+)
FVB/NJ	MGP_FVBNJ_G0021460	protein coding gene	Chr14:109554034-109580713 (+)
LP/J	MGP_LPJ_G0021550	protein coding gene	Chr14:116741453-116769870 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021487	protein coding gene	Chr14:129897536-129929468 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022076	protein coding gene	Chr14:114371541-114400876 (+)
PWK/PhJ	MGP_PWKPhJ_G0020651	protein coding gene	Chr14:108206873-108232518 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020489	protein coding gene	Chr14:110623940-110650943 (+)
WSB/EiJ	MGP_WSBEiJ_G0020962	protein coding gene	Chr14:115170065-115200272 (+)

Human Ortholog

GPR180, G protein-coupled receptor 180

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR180, G protein-coupled receptor 180
Synonyms

ITR
Links

HGNC:28899

NCBI Gene ID: 160897

neXtProt AC: NX_Q86V85

UniProt: Q86V85
Chr Location

13q32.1; chr13:94601857-94634661 (+) GRCh38

MGI Vertebrate Homology

Gpr180 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPR180
Gene Tree

Gpr180

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Gpr180
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are resistant to cuff-induced intimal thickening of the femoral artery.

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All GO Annotations

3
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

30
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpr180

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All Sequences

50
RefSeq

8
UniProt

2
CCDS

CCDS27333.1

Ensembl

ENSMUSG00000022131 (Evidence)
NCBI Gene

58245

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022131	Ensembl Gene Model \| MGI Sequence Detail	26104	C57BL/6J	± kb
transcript	ENSMUST00000022728	Ensembl \| MGI Sequence Detail	1875	Not Applicable
polypeptide	ENSMUSP00000022728	Ensembl \| MGI Sequence Detail	441	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031932 integral membrane protein GPR180

(term hierarchy)
InterPro Domains

IPR047831 GPR180/TMEM145

IPR019336 GPR180/TMEM145, transmembrane domain
GlyGen

Q8BPS4 1 site, 1 N-linked glycan (1 site)

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All nucleic 30

cDNA 30

Microarray probesets 3

Summaries

All 35

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 10
Earliest

J:67314 Roix J, et al., Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14. Genetics. 2001 Feb;157(2):803-15
Latest

J:344931 Zhang Y, et al., Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway. Nutrients. 2023 Apr 11;15(8)

TSS for Gpr180:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127167	Chr14:118374513-118374590 (+)	-18 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24