Acp6 MGI Mouse Gene Detail - MGI:1931010 - acid phosphatase 6, lysophosphatidic

Symbol

Acp6
Name

acid phosphatase 6, lysophosphatidic
Synonyms

5730559A09Rik, ACPL1, mPACPL1

Feature Type

protein coding gene
IDs

MGI:1931010
NCBI Gene: 66659
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:97066070-97083892 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 42.04 cM
Mapping Data

2 experiments

SNPs within 2kb

480 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931010	protein coding gene	Chr3:97066070-97084615 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027638	protein coding gene	Chr3:98076522-98095102 (+)
A/J	MGP_AJ_G0027600	protein coding gene	Chr3:94944278-94962796 (+)
AKR/J	MGP_AKRJ_G0027567	protein coding gene	Chr3:97214764-97233272 (+)
BALB/cJ	MGP_BALBcJ_G0027610	protein coding gene	Chr3:94754039-94776075 (+)
C3H/HeJ	MGP_C3HHeJ_G0027342	protein coding gene	Chr3:97493737-97512259 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028056	protein coding gene	Chr3:101697526-101716082 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025397	protein coding gene	Chr3:91180641-91199258 (+)
CAST/EiJ	MGP_CASTEiJ_G0026797	protein coding gene	Chr3:96755516-96774154 (+)
CBA/J	MGP_CBAJ_G0027317	protein coding gene	Chr3:105353586-105372105 (+)
DBA/2J	MGP_DBA2J_G0027460	protein coding gene	Chr3:94254084-94272636 (+)
FVB/NJ	MGP_FVBNJ_G0027429	protein coding gene	Chr3:92267416-92288258 (+)
LP/J	MGP_LPJ_G0027565	protein coding gene	Chr3:99346422-99365217 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027455	protein coding gene	Chr3:111438843-111458366 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028110	protein coding gene	Chr3:96809083-96828635 (+)
PWK/PhJ	MGP_PWKPhJ_G0026522	protein coding gene	Chr3:94102054-94120558 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026344	protein coding gene	Chr3:95083215-95101989 (+)
WSB/EiJ	MGP_WSBEiJ_G0026875	protein coding gene	Chr3:97254592-97276234 (+)

Human Ortholog

ACP6, acid phosphatase 6, lysophosphatidic

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACP6, acid phosphatase 6, lysophosphatidic
Synonyms

ACPL1, LPAP, PACPL1
Links

HGNC:29609

NCBI Gene ID: 51205

neXtProt AC: NX_Q9NPH0

UniProt: Q9NPH0
Chr Location

1q21.2; chr1:147629652-147670524 (-) GRCh38

MGI Vertebrate Homology

Acp6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACP6
Gene Tree

Acp6

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

14
Radiation induced

1
Targeted

4
Genomic Mutations

3 involving Acp6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested.

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All GO Annotations

13
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

836
Tissues

96
cDNA Data

13
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acp6

ZFIN acp6

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All Sequences

53
RefSeq

4
UniProt

1
CCDS

CCDS17653.1

Ensembl

ENSMUSG00000028093 (Evidence)
NCBI Gene

66659

			Length	Strain/Species	Flank
genomic	66659	NCBI Gene Model \| MGI Sequence Detail	17823	C57BL/6J	± kb
transcript	NM_019800	RefSeq \| MGI Sequence Detail	1756	C57BL/6
polypeptide	Q8BP40	UniProt \| EBI \| MGI Sequence Detail	418	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003648 lysophosphatidic acid phosphatase type 6

(term hierarchy)
EC

3.1.3.2
InterPro Domains

IPR050645 Histidine Acid Phosphatase

IPR033379 Histidine acid phosphatase active site

IPR029033 Histidine phosphatase superfamily

IPR000560 Histidine phosphatase superfamily, clade-2
GlyGen

Q8BP40 1 site, 1 O-linked glycan (1 site)

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 5

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MGI:1913909, MGI:2139897

Summaries

All 48

Developmental Gene Expression 2

Diseases 1

Gene Ontology 8

Phenotypes 16
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acp6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30784	Chr3:97066083-97066136 (+)	40 bp
Tssr30785	Chr3:97066139-97066161 (+)	80 bp
Tssr30786	Chr3:97066168-97066186 (+)	107 bp
Tssr30787	Chr3:97066326-97066353 (+)	270 bp
Tssr30788	Chr3:97066363-97066380 (+)	302 bp
Tssr30789	Chr3:97066395-97066417 (+)	336 bp
Tssr30790	Chr3:97070305-97070318 (+)	4,242 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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