Sertad2 MGI Mouse Gene Detail - MGI:1931026

Symbol

Sertad2
Name

SERTA domain containing 2
Synonyms

mKIAA0127, Sei2, SEI-2, Trip-Br2

Feature Type

protein coding gene
IDs

MGI:1931026
NCBI Gene: 58172
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr11:20493253-20603021 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 13.03 cM, cytoband A3.2
Mapping Data

3 experiments

SNPs within 2kb

2173 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931026	protein coding gene	Chr11:20493166-20603023 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018067	protein coding gene	Chr11:18091384-18203468 (+)
A/J	MGP_AJ_G0018040	protein coding gene	Chr11:17466020-17574189 (+)
AKR/J	MGP_AKRJ_G0018004	protein coding gene	Chr11:18086395-18203974 (+)
BALB/cJ	MGP_BALBcJ_G0018008	protein coding gene	Chr11:17585584-17695192 (+)
C3H/HeJ	MGP_C3HHeJ_G0017822	protein coding gene	Chr11:17978629-18095132 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018460	protein coding gene	Chr11:18899246-19021472 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016118	protein coding gene	Chr11:16442200-16548875 (+)
CAST/EiJ	MGP_CASTEiJ_G0017383	protein coding gene	Chr11:17944767-18065641 (+)
CBA/J	MGP_CBAJ_G0017796	protein coding gene	Chr11:19736348-19863900 (+)
DBA/2J	MGP_DBA2J_G0017906	protein coding gene	Chr11:17416577-17526893 (+)
FVB/NJ	MGP_FVBNJ_G0017898	protein coding gene	Chr11:17152464-17267564 (+)
LP/J	MGP_LPJ_G0017977	protein coding gene	Chr11:18251088-18366882 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017924	protein coding gene	Chr11:20170945-20291796 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018501	protein coding gene	Chr11:18161315-18274425 (+)
PWK/PhJ	MGP_PWKPhJ_G0017163	protein coding gene	Chr11:17434822-17543594 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016961	protein coding gene	Chr11:17902865-18018234 (+)
WSB/EiJ	MGP_WSBEiJ_G0017437	protein coding gene	Chr11:17815657-17928247 (+)

Human Ortholog

SERTAD2, SERTA domain containing 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERTAD2, SERTA domain containing 2
Synonyms

Sei-2, TRIP-Br2, TRIPBR2
Links

HGNC:30784

NCBI Gene ID: 9792

neXtProt AC: NX_Q14140

UniProt: Q14140
Chr Location

2p14; chr2:64631621-64751005 (-) GRCh38

MGI Vertebrate Homology

Sertad2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SERTAD2
Gene Tree

Sertad2

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Phenotype Summary

29 phenotypes from 1 allele in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

86
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

83
Targeted

1
Genomic Mutations

1 involving Sertad2
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

81 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit enhanced lipolysis, thermogenesis, and oxidative metabolism with resistance to diet induced obesity and steatosis and improved when fed a high fat diet.

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

784
Tissues

66
cDNA Data

113
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SERTAD2

Xenbase sertad2

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All Sequences

61
RefSeq

10
UniProt

4
CCDS

CCDS24458.1

Ensembl

ENSMUSG00000049800 (Evidence)
NCBI Gene

58172

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049800	Ensembl Gene Model \| MGI Sequence Detail	109769	C57BL/6J	± kb
transcript	ENSMUST00000093292	Ensembl \| MGI Sequence Detail	5647	Not Applicable
polypeptide	ENSMUSP00000090981	Ensembl \| MGI Sequence Detail	309	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014712 SERTA domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR052262 E2F-responsive SERTA domain-containing protein

IPR009263 SERTA domain

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All nucleic 114

cDNA 113

Primer pair 1

Microarray probesets 4

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MGI:2144409

Summaries

All 51

Developmental Gene Expression 9

Gene Ontology 5

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:275279 Qiang G, et al., Transcription regulator TRIP-Br2 mediates ER stress-induced brown adipocytes dysfunction. Sci Rep. 2017 Jan 9;7:40215

TSS for Sertad2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100506	Chr11:20492870-20492876 (+)	-380 bp
Tssr100507	Chr11:20492889-20492900 (+)	-358 bp
Tssr100508	Chr11:20492913-20492922 (+)	-335 bp
Tssr100509	Chr11:20492925-20492937 (+)	-322 bp
Tssr100510	Chr11:20493130-20493183 (+)	-96 bp
Tssr100511	Chr11:20493246-20493268 (+)	4 bp
Tssr100512	Chr11:20493307-20493336 (+)	69 bp
Tssr100513	Chr11:20544041-20544044 (+)	50,790 bp
Tssr100514	Chr11:20581956-20582006 (+)	88,728 bp
Tssr100515	Chr11:20582048-20582059 (+)	88,801 bp
Tssr100516	Chr11:20582097-20582108 (+)	88,850 bp
Tssr100517	Chr11:20597149-20597156 (+)	103,900 bp
Tssr100518	Chr11:20597159-20597179 (+)	103,916 bp
Tssr100519	Chr11:20597234-20597239 (+)	103,984 bp
Tssr100520	Chr11:20597248-20597253 (+)	103,998 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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