Tac4 MGI Mouse Gene Detail - MGI:1931130

Symbol

Tac4
Name

tachykinin 4
Synonyms

hemokinin I (HK-1), PPT-C

Feature Type

protein coding gene
IDs

MGI:1931130
NCBI Gene: 93670
Alliance

gene page

Sequence Map

Chr11:95152355-95160091 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 59.01 cM
Mapping Data

1 experiment

SNPs within 2kb

350 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931130	protein coding gene	Chr11:95152355-95160091 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018979	protein coding gene	Chr11:97452947-97460694 (+)
A/J	MGP_AJ_G0018947	protein coding gene	Chr11:93522401-93530163 (+)
AKR/J	MGP_AKRJ_G0018917	protein coding gene	Chr11:96413552-96421300 (+)
BALB/cJ	MGP_BALBcJ_G0018920	protein coding gene	Chr11:93994162-94001896 (+)
C3H/HeJ	MGP_C3HHeJ_G0018734	protein coding gene	Chr11:96538304-96546052 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019372	protein coding gene	Chr11:100516601-100524337 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017003	protein coding gene	Chr11:91007637-91015560 (+)
CAST/EiJ	MGP_CASTEiJ_G0018288	protein coding gene	Chr11:97335501-97343189 (+)
CBA/J	MGP_CBAJ_G0018705	protein coding gene	Chr11:104617694-104625462 (+)
DBA/2J	MGP_DBA2J_G0018813	protein coding gene	Chr11:93095636-93103526 (+)
FVB/NJ	MGP_FVBNJ_G0018802	protein coding gene	Chr11:92561736-92570344 (+)
LP/J	MGP_LPJ_G0018883	protein coding gene	Chr11:98019424-98027142 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018829	protein coding gene	Chr11:104664557-104672310 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019412	protein coding gene	Chr11:96676921-96684657 (+)
PWK/PhJ	MGP_PWKPhJ_G0018059	protein coding gene	Chr11:94017027-94024833 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017848	protein coding gene	Chr11:96361918-96369736 (+)
WSB/EiJ	MGP_WSBEiJ_G0018337	protein coding gene	Chr11:96598492-96606258 (+)

Human Ortholog

TAC4, tachykinin precursor 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TAC4, tachykinin precursor 4
Synonyms

EK, HK-1, HK1, PPT-C
Links

HGNC:16641

NCBI Gene ID: 255061

neXtProt AC: NX_Q86UU9

UniProt: Q86UU9
Chr Location

17q21.33; chr17:49838300-49848069 (-) GRCh38

MGI Vertebrate Homology

Tac4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TAC4
Gene Tree

Tac4

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Gene trapped

4
Targeted

4
Genomic Mutations

2 involving Tac4
Incidental Mutations

CvDC
Find Mice (IMSR)

10 strains or lines available

Mice homozygous for a knock-out allele exhibit increased pro-B cells without an increase in mature B cells.

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All GO Annotations

30
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

21
cDNA Data

4
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS25274.1

Ensembl

ENSMUSG00000020872 (Evidence)
NCBI Gene

93670

			Length	Strain/Species	Flank
genomic	93670	NCBI Gene Model \| MGI Sequence Detail	7737	C57BL/6J	± kb
transcript	NM_053093	RefSeq \| MGI Sequence Detail	1262	Not Specified
polypeptide	Q99N14	UniProt \| EBI \| MGI Sequence Detail	128	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016005 tachykinin-4

(term hierarchy)
InterPro Domains

IPR013055 Tachykinin/Neurokinin-like, conserved site

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All nucleic 7

Genomic 2

cDNA 4

Primer pair 1

Microarray probesets 2

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MGI:2144537

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 17
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:342660 Nethander M, et al., An atlas of genetic determinants of forearm fracture. Nat Genet. 2023 Nov;55(11):1820-1830

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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