Mtes1 QTL Detail

Summary

• Symbol
  Mtes1
• Name
  Metastasis efficiency suppressor gene 1

• Feature Type
  QTL
• IDs
  MGI:1931151
  NCBI Gene: 246088
• Candidate Genes
  5 Genes

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 19, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  3 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype from multigenic genotypes
  2 phenotype references
  

• All Mutations and Alleles
  4
• QTL
  4
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  246088

References

• Summaries
  All 6

  Phenotypes 2
• Earliest
  J:73358 Hunter KW, et al., Predisposition to efficient mammary tumor metastatic progression is linked to the breast cancer metastasis suppressor gene Brms1. Cancer Res. 2001 Dec 15;61(24):8866-72
• Latest
  J:105038 Reilly KM, et al., An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model. Cancer Res. 2006 Jan 1;66(1):62-8

Candidate Genes for Mtes1:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Kcnk7	Chr19:5754395-5757137 (+)	J:103849	The authors showed a representation of approximately 110kb of gemomic mouse Chromosome 19. The markers were ordered as Centromere - Rela - Sipa1 - Pcnxl3 - Map3k11 - Kcnk7 - Telomere. Evidence is also provided using the two strains of mice with high metastatic efficiency (AKR/J and FVB/NJ) and the two strains with low metastatic efficiency (DBA/2J and NZB/B1NJ) that mouse Sipa1 may be a candidate for QTL Mtes1.
Map3k11	Chr19:5738770-5752893 (+)	J:103849	The authors showed a representation of approximately 110kb of gemomic mouse Chromosome 19. The markers were ordered as Centromere - Rela - Sipa1 - Pcnxl3 - Map3k11 - Kcnk7 - Telomere. Evidence is also provided using the two strains of mice with high metastatic efficiency (AKR/J and FVB/NJ) and the two strains with low metastatic efficiency (DBA/2J and NZB/B1NJ) that mouse Sipa1 may be a candidate for QTL Mtes1.
Pcnx3	Chr19:5714663-5738936 (-)	J:103849	The authors showed a representation of approximately 110kb of gemomic mouse Chromosome 19. The markers were ordered as Centromere - Rela - Sipa1 - Pcnxl3 - Map3k11 - Kcnk7 - Telomere. Evidence is also provided using the two strains of mice with high metastatic efficiency (AKR/J and FVB/NJ) and the two strains with low metastatic efficiency (DBA/2J and NZB/B1NJ) that mouse Sipa1 may be a candidate for QTL Mtes1.
Rela	Chr19:5687511-5698158 (+)	J:103849	The authors showed a representation of approximately 110kb of gemomic mouse Chromosome 19. The markers were ordered as Centromere - Rela - Sipa1 - Pcnxl3 - Map3k11 - Kcnk7 - Telomere. Evidence is also provided using the two strains of mice with high metastatic efficiency (AKR/J and FVB/NJ) and the two strains with low metastatic efficiency (DBA/2J and NZB/B1NJ) that mouse Sipa1 may be a candidate for QTL Mtes1.
Sipa1	Chr19:5701213-5713735 (-)	J:103849	The authors showed a representation of approximately 110kb of gemomic mouse Chromosome 19. The markers were ordered as Centromere - Rela - Sipa1 - Pcnxl3 - Map3k11 - Kcnk7 - Telomere. Evidence is also provided using the two strains of mice with high metastatic efficiency (AKR/J and FVB/NJ) and the two strains with low metastatic efficiency (DBA/2J and NZB/B1NJ) that mouse Sipa1 may be a candidate for QTL Mtes1.