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Wwox Gene Detail
Summary
  • Symbol
    Wwox
  • Name
    WW domain-containing oxidoreductase
  • Synonyms
    5330426P09Rik, 9030416C10Rik, WOX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931237
    NCBI Gene: 80707
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:115166395-116079447 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 60.99 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    28537 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931237
 protein coding gene Chr8:115166377-116079451 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034161
 protein coding gene Chr8:117417106-118373081 (+)
A/J MGP_AJ_G0034141
 protein coding gene Chr8:112637549-113568723 (+)
AKR/J MGP_AKRJ_G0034068
 protein coding gene Chr8:115916949-116866906 (+)
BALB/cJ MGP_BALBcJ_G0034135
 protein coding gene Chr8:112822510-113749638 (+)
C3H/HeJ MGP_C3HHeJ_G0033846
 protein coding gene Chr8:116613017-117591401 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034655
 protein coding gene Chr8:121435174-122396436 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031597
 protein coding gene Chr8:105624521-106540350 (+)
CAST/EiJ MGP_CASTEiJ_G0033173
 protein coding gene Chr8:116339846-117341255 (+)
CBA/J MGP_CBAJ_G0033819
 protein coding gene Chr8:125721641-126758293 (+)
DBA/2J MGP_DBA2J_G0033975
 protein coding gene Chr8:111871611-112794745 (+)
FVB/NJ MGP_FVBNJ_G0033918
 protein coding gene Chr8:110858076-111775408 (+)
LP/J MGP_LPJ_G0034064
 protein coding gene Chr8:117556740-118508220 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033965
 protein coding gene Chr8:128473588-129456761 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034673
 protein coding gene Chr8:115970290-116934996 (+)
PWK/PhJ MGP_PWKPhJ_G0032875
 protein coding gene Chr8:111557482-112482630 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032715
 protein coding gene Chr8:114628651-115598734 (+)
WSB/EiJ MGP_WSBEiJ_G0033289
 protein coding gene Chr8:116659732-117636140 (+)



Homology
more
  • Human Ortholog
    WWOX, WW domain containing oxidoreductase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WWOX, WW domain containing oxidoreductase
  • Synonyms
    D16S432E, DEE28, EIEE28, FOR, FRA16D, HHCMA56, PRO0128, SCAR12, SDR41C1, WOX1
  • Links
    NCBI Gene ID: 51741
    neXtProt AC: NX_Q9NZC7
    UniProt: Q9NZC7

  • Chr Location
    16q23.1-q23.2; chr16:78099400-79212667 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Wwox mouse models; 4 with human WWOX associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    103 phenotypes from 6 alleles in 7 genetic backgrounds
    8 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in premature death and increased incidence of tumor development. Reduced male fertility and testicular atrophy are also observed in mice with a hypomorphic allele. Homozygosity for the p.P47T mutation affects brain morphology and leads to seizures, motor, anxiety and social deficits and reduced lifespan.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    904
  • Tissues
    150
  • cDNA Data
    5
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004637 Ensembl Gene Model | MGI Sequence Detail 913053 C57BL/6J ±  kb
    transcript ENSMUST00000004756 Ensembl | MGI Sequence Detail 2244 Not Applicable  
    polypeptide ENSMUSP00000004756 Ensembl | MGI Sequence Detail 414 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1918787, MGI:1925520
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 9
      Phenotypes 35
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:350323 Zeng Z, et al., Endothelial knockdown of the tumor suppressor, WWOX, increases inflammation in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2024 Jun 1;326(6):L687-L697
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory