Pbx4 MGI Mouse Gene Detail - MGI:1931321 - pre B cell leukemia homeobox 4

Symbol

Pbx4
Name

pre B cell leukemia homeobox 4
Synonyms

2410015M21Rik

Feature Type

protein coding gene
IDs

MGI:1931321
NCBI Gene: 80720
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:70285141-70324942 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 33.92 cM, cytoband C
Mapping Data

3 experiments

SNPs within 2kb

1196 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931321	protein coding gene	Chr8:70285127-70324942 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033679	protein coding gene	Chr8:70045572-70101557 (+)
A/J	MGP_AJ_G0033662	protein coding gene	Chr8:67210508-67253270 (+)
AKR/J	MGP_AKRJ_G0033587	protein coding gene	Chr8:69116941-69160154 (+)
BALB/cJ	MGP_BALBcJ_G0033658	protein coding gene	Chr8:67432572-67472714 (+)
C3H/HeJ	MGP_C3HHeJ_G0033368	protein coding gene	Chr8:69770210-69820178 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034175	protein coding gene	Chr8:72715134-72769355 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031119	protein coding gene	Chr8:62036902-62077560 (+)
CAST/EiJ	MGP_CASTEiJ_G0032693	protein coding gene	Chr8:69239950-69281415 (+)
CBA/J	MGP_CBAJ_G0033346	protein coding gene	Chr8:75363806-75407444 (+)
DBA/2J	MGP_DBA2J_G0033500	protein coding gene	Chr8:66937133-66979589 (+)
FVB/NJ	MGP_FVBNJ_G0033441	protein coding gene	Chr8:66029742-66073940 (+)
LP/J	MGP_LPJ_G0033587	protein coding gene	Chr8:70110516-70151854 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033485	protein coding gene	Chr8:78023276-78064035 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034193	protein coding gene	Chr8:69297320-69342136 (+)
PWK/PhJ	MGP_PWKPhJ_G0032401	protein coding gene	Chr8:66221329-66263748 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032237	protein coding gene	Chr8:68276119-68318435 (+)
WSB/EiJ	MGP_WSBEiJ_G0032808	protein coding gene	Chr8:69665630-69711111 (+)

Human Ortholog

PBX4, PBX homeobox 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PBX4, PBX homeobox 4
Links

HGNC:13403

NCBI Gene ID: 80714

neXtProt AC: NX_Q9BYU1

UniProt: Q9BYU1
Chr Location

19p13.11; chr19:19561707-19618693 (-) GRCh38

MGI Vertebrate Homology

Pbx4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PBX4
Gene Tree

Pbx4

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Phenotype Summary

28 phenotypes from 3 alleles in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

7
Gene trapped

8
Genomic Mutations

1 involving Pbx4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit no apparent abnormality in spermatogenesis but show postnatal growth retardation, inactivity, shorter hindlimbs and hindlimb disability, anemia, lower numbers of reticulocytes and lymphocytes, a decreased erythropoietin level, and premature death.

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

919
Tissues

150
cDNA Data

9
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN pbx4

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All Sequences

65
RefSeq

16
UniProt

4
CCDS

CCDS22352.1

Ensembl

ENSMUSG00000031860 (Evidence)
NCBI Gene

80720

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031860	Ensembl Gene Model \| MGI Sequence Detail	39802	C57BL/6J	± kb
transcript	ENSMUST00000081503	Ensembl \| MGI Sequence Detail	1560	Not Applicable
polypeptide	ENSMUSP00000080219	Ensembl \| MGI Sequence Detail	378	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012329 pre-B-cell leukemia transcription factor 4

(term hierarchy)
InterPro Domains

IPR001356 Homeobox domain

IPR008422 Homeobox KN domain

IPR009057 Homeobox-like domain superfamily

IPR005542 PBX, PBC domain

IPR050224 Three Amino acid Loop Extension (TALE) homeobox

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All nucleic 16

Genomic 2

cDNA 10

Primer pair 3

Other 1

Microarray probesets 2

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MGI:1917006, MGI:2142537, MGI:2142744

Summaries

All 45

Developmental Gene Expression 12

Gene Ontology 4

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:349843 Ning Y, et al., Transcription factor PBX4 regulates limb development and haematopoiesis in mice. Cell Prolif. 2024 May;57(5):e13580

TSS for Pbx4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77683	Chr8:70285135-70285185 (+)	19 bp
Tssr77684	Chr8:70285283-70285362 (+)	182 bp
Tssr77685	Chr8:70285395-70285404 (+)	259 bp
Tssr77686	Chr8:70285412-70285431 (+)	281 bp
Tssr77687	Chr8:70285448-70285459 (+)	313 bp
Tssr77688	Chr8:70301971-70301991 (+)	16,840 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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