Slc43a1 MGI Mouse Gene Detail - MGI:1931352 - solute carrier family 43, member 1

Symbol

Slc43a1
Name

solute carrier family 43, member 1
Synonyms

2610016F07Rik, Lat3, PB39, Pov1

Feature Type

protein coding gene
IDs

MGI:1931352
NCBI Gene: 72401
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:84669196-84693930 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 49.45 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

587 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931352	protein coding gene	Chr2:84669194-84693938 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025914	protein coding gene	Chr2:85539225-85564860 (+)
A/J	MGP_AJ_G0025888	protein coding gene	Chr2:82233124-82257889 (+)
AKR/J	MGP_AKRJ_G0025858	protein coding gene	Chr2:84354742-84379424 (+)
BALB/cJ	MGP_BALBcJ_G0025885	protein coding gene	Chr2:82359544-82384994 (+)
C3H/HeJ	MGP_C3HHeJ_G0025644	protein coding gene	Chr2:84592114-84617557 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026331	protein coding gene	Chr2:88189572-88215452 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023733	protein coding gene	Chr2:79049062-79074300 (+)
CAST/EiJ	MGP_CASTEiJ_G0025105	protein coding gene	Chr2:85124908-85150824 (+)
CBA/J	MGP_CBAJ_G0025625	protein coding gene	Chr2:91339033-91363813 (+)
DBA/2J	MGP_DBA2J_G0025756	protein coding gene	Chr2:81764006-81788802 (+)
FVB/NJ	MGP_FVBNJ_G0025719	protein coding gene	Chr2:81019082-81044846 (+)
LP/J	MGP_LPJ_G0025844	protein coding gene	Chr2:85333689-85358465 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025749	protein coding gene	Chr2:93656326-93681018 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026387	protein coding gene	Chr2:84595429-84621359 (+)
PWK/PhJ	MGP_PWKPhJ_G0024849	protein coding gene	Chr2:81607890-81632794 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024653	protein coding gene	Chr2:84729118-84753660 (+)
WSB/EiJ	MGP_WSBEiJ_G0025175	protein coding gene	Chr2:85252941-85277708 (+)

Human Ortholog

SLC43A1, solute carrier family 43 member 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC43A1, solute carrier family 43 member 1
Synonyms

LAT3, PB39, POV1, R00504
Links

HGNC:9225

NCBI Gene ID: 8501

neXtProt AC: NX_O75387

UniProt: O75387
Chr Location

11q12.1; chr11:57484534-57515780 (-) GRCh38

MGI Vertebrate Homology

Slc43a1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC43A1
Gene Tree

Slc43a1

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Phenotype Summary

11 phenotype references

All Mutations and Alleles

14
Chemically induced (other)

1
Gene trapped

8
Targeted

5
Genomic Mutations

3 involving Slc43a1
Find Mice (IMSR)

27 strains or lines available

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All GO Annotations

30
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

836
Tissues

101
cDNA Data

12
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc43a1

ZFIN slc43a1a, slc43a1b

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All Sequences

72
RefSeq

21
UniProt

4
CCDS

CCDS38162.1, CCDS38163.1, CCDS50624.1

Ensembl

ENSMUSG00000027075 (Evidence)
NCBI Gene

72401

			Length	Strain/Species	Flank
genomic	72401	NCBI Gene Model \| MGI Sequence Detail	24735	C57BL/6J	± kb
transcript	NM_001081349	RefSeq \| MGI Sequence Detail	2539	C57BL/6
polypeptide	Q8BSM7	UniProt \| EBI \| MGI Sequence Detail	564	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015141 large neutral amino acids transporter small subunit 3

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR036259 MFS transporter superfamily
GlyGen

Q8BSM7 4 sites

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All nucleic 13

cDNA 12

Other 1

Microarray probesets 5

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MGI:1919651, MGI:2138819

Summaries

All 45

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 11
Earliest

J:49540 Cole KA, et al., cDNA sequencing and analysis of POV1 (PB39): a novel gene up-regulated in prostate cancer. Genomics. 1998 Jul 15;51(2):282-7
Latest

J:353480 Huang S, et al., Mutations in linker-2 of KLF1 impair expression of membrane transporters and cytoskeletal proteins causing hemolysis. Nat Commun. 2024 Aug 15;15(1):7019

TSS for Slc43a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18701	Chr2:84669752-84669768 (+)	564 bp
Tssr18702	Chr2:84670691-84670708 (+)	1,504 bp
Tssr18703	Chr2:84670738-84670781 (+)	1,564 bp
Tssr18704	Chr2:84670956-84670984 (+)	1,774 bp
Tssr18705	Chr2:84670993-84671006 (+)	1,804 bp
Tssr18706	Chr2:84671021-84671032 (+)	1,831 bp
Tssr18707	Chr2:84681785-84681806 (+)	12,600 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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