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Cblc Gene Detail
Summary
  • Symbol
    Cblc
  • Name
    Casitas B-lineage lymphoma c
  • Synonyms
    2310076I21Rik, 2310079L19Rik, Cbl3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931457
    NCBI Gene: 80794
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19513643-19530734 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.94 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    591 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931457
 protein coding gene Chr7:19512806-19530734 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031796
 protein coding gene Chr7:17829680-17848293 (-)
A/J MGP_AJ_G0031772
 protein coding gene Chr7:17428667-17447723 (-)
AKR/J MGP_AKRJ_G0031698
 protein coding gene Chr7:17917192-17938649 (-)
BALB/cJ MGP_BALBcJ_G0031777
 protein coding gene Chr7:17637201-17656250 (-)
C3H/HeJ MGP_C3HHeJ_G0031499
 protein coding gene Chr7:18180912-18206769 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032243
 protein coding gene Chr7:18706136-18728039 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029309
 protein coding gene Chr7:19077761-19095100 (-)
CAST/EiJ MGP_CASTEiJ_G0030842
 protein coding gene Chr7:14639452-14659796 (-)
CBA/J MGP_CBAJ_G0031461
 protein coding gene Chr7:19386752-19411135 (-)
DBA/2J MGP_DBA2J_G0031616
 protein coding gene Chr7:17382763-17402057 (-)
FVB/NJ MGP_FVBNJ_G0031568
 protein coding gene Chr7:17257267-17275497 (-)
LP/J MGP_LPJ_G0031699
 protein coding gene Chr7:18136766-18158900 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031604
 protein coding gene Chr7:19199332-19228057 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032271
 protein coding gene Chr7:17532449-17552089 (-)
PWK/PhJ MGP_PWKPhJ_G0030566
 protein coding gene Chr7:14486130-14505265 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030393
 protein coding gene Chr7:12236319-12259506 (-)
WSB/EiJ MGP_WSBEiJ_G0030942
 protein coding gene Chr7:17749225-17769992 (-)



Homology
more
  • Human Ortholog
    CBLC, Cbl proto-oncogene C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBLC, Cbl proto-oncogene C
  • Synonyms
    CBL-3, CBL-SL, RNF57
  • Links
    NCBI Gene ID: 23624
    neXtProt AC: NX_Q9ULV8
    UniProt: Q9ULV8

  • Chr Location
    19q13.32; chr19:44777869-44800652 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Homozygous null mice are viable, fertile, and show no abnormalities of the epithelium or other tissues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    900
  • Tissues
    57
  • cDNA Data
    33
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 80794 NCBI Gene Model | MGI Sequence Detail 17092 C57BL/6J ±  kb
transcript NM_023224 RefSeq | MGI Sequence Detail 1677 C57BL/6  
polypeptide Q80XL1 UniProt | EBI | MGI Sequence Detail 496 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 36
    cDNA 35
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1913812, MGI:1919198
References
more
  • Summaries
    All 41
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:279933 Zhang X, et al., Loss-of-function mutations in FREM2 disrupt eye morphogenesis. Exp Eye Res. 2019 Apr;181:302-312
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory