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Dbr1 Gene Detail
Summary
  • Symbol
    Dbr1
  • Name
    debranching RNA lariats 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931520
    NCBI Gene: 83703
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:99457852-99466554 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 51.86 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931520
 protein coding gene Chr9:99457839-99467060 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035171
 protein coding gene Chr9:100951489-100960601 (+)
A/J MGP_AJ_G0035152
 protein coding gene Chr9:97390938-97399728 (+)
AKR/J MGP_AKRJ_G0035084
 protein coding gene Chr9:99764007-99772709 (+)
BALB/cJ MGP_BALBcJ_G0035145
 protein coding gene Chr9:97077688-97086402 (+)
C3H/HeJ MGP_C3HHeJ_G0034855
 protein coding gene Chr9:100159152-100167898 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035665
 protein coding gene Chr9:103841041-103849743 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032564
 protein coding gene Chr9:95122627-95132851 (+)
CAST/EiJ MGP_CASTEiJ_G0034166
 protein coding gene Chr9:99982242-99990974 (+)
CBA/J MGP_CBAJ_G0034823
 protein coding gene Chr9:107407200-107415893 (+)
DBA/2J MGP_DBA2J_G0034985
 protein coding gene Chr9:96899291-96908510 (+)
FVB/NJ MGP_FVBNJ_G0034933
 protein coding gene Chr9:95721533-95730339 (+)
LP/J MGP_LPJ_G0035061
 protein coding gene Chr9:101200000-101208732 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034972
 protein coding gene Chr9:109306567-109315271 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035687
 protein coding gene Chr9:100010099-100024022 (+)
PWK/PhJ MGP_PWKPhJ_G0033873
 protein coding gene Chr9:97116811-97125537 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033708
 protein coding gene Chr9:100072195-100080946 (+)
WSB/EiJ MGP_WSBEiJ_G0034286
 protein coding gene Chr9:99895879-99905915 (+)



Homology
more
  • Human Ortholog
    DBR1, debranching RNA lariats 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DBR1, debranching RNA lariats 1
  • Synonyms
    XGIP
  • Links
    NCBI Gene ID: 51163
    neXtProt AC: NX_Q9UK59
    UniProt: Q9UK59

  • Chr Location
    3q22.3; chr3:138160988-138174949 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DBR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show normal blastocyst formation but exhibit complete embryonic lethality prior to organogenesis. Homozygotes for a hypomorphic gene trap allele exhibit prenatal lethality while heterozygotes show impaired class switch recombination in B cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1000
  • Tissues
    87
  • cDNA Data
    30
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032469 Ensembl Gene Model | MGI Sequence Detail 8703 C57BL/6J ±  kb
    transcript ENSMUST00000066650 Ensembl | MGI Sequence Detail 2261 Not Applicable  
    polypeptide ENSMUSP00000070991 Ensembl | MGI Sequence Detail 550 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000006299 lariat debranching enzyme
      (term hierarchy)
    • EC
      3.1.4.-
    • InterPro Domains
      IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
      IPR007708 Lariat debranching enzyme, C-terminal
      IPR041816 Lariat debranching enzyme, N-terminal metallophosphatase domain
      IPR029052 Metallo-dependent phosphatase-like
    • GlyGen
      Q923B1 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 30
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143276
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:64827 Kim JW, et al., Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants. Nucleic Acids Res. 2000 Sep 15;28(18):3666-73
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory