Pum2 MGI Mouse Gene Detail - MGI:1931751 - pumilio RNA-binding family member 2

Symbol

Pum2
Name

pumilio RNA-binding family member 2
Synonyms

5730503J23Rik, mKIAA0235, Pumm2

Feature Type

protein coding gene
IDs

MGI:1931751
NCBI Gene: 80913
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr12:8724134-8802581 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 3.92 cM, cytoband A1.3
Mapping Data

2 experiments

SNPs within 2kb

1049 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931751	protein coding gene	Chr12:8724092-8802583 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019587	protein coding gene	Chr12:5743530-5822585 (+)
A/J	MGP_AJ_G0019554	protein coding gene	Chr12:5581463-5659766 (+)
AKR/J	MGP_AKRJ_G0019524	protein coding gene	Chr12:5961709-6039805 (+)
BALB/cJ	MGP_BALBcJ_G0019529	protein coding gene	Chr12:5706376-5785466 (+)
C3H/HeJ	MGP_C3HHeJ_G0019335	protein coding gene	Chr12:5782102-5870383 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019978	protein coding gene	Chr12:5919745-6002072 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017603	protein coding gene	Chr12:5396526-5473268 (+)
CAST/EiJ	MGP_CASTEiJ_G0018890	protein coding gene	Chr12:5776092-5862564 (+)
CBA/J	MGP_CBAJ_G0019306	protein coding gene	Chr12:6449960-6535281 (+)
DBA/2J	MGP_DBA2J_G0019419	protein coding gene	Chr12:5530896-5614806 (+)
FVB/NJ	MGP_FVBNJ_G0019410	protein coding gene	Chr12:5506625-5585435 (+)
LP/J	MGP_LPJ_G0019490	protein coding gene	Chr12:5787674-5869399 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019443	protein coding gene	Chr12:6239148-6348159 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020017	protein coding gene	Chr12:5698389-5777908 (+)
PWK/PhJ	MGP_PWKPhJ_G0018656	protein coding gene	Chr12:5599366-5679795 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018447	protein coding gene	Chr12:5709416-5794278 (+)
WSB/EiJ	MGP_WSBEiJ_G0018941	protein coding gene	Chr12:5754266-5841129 (+)

Human Ortholog

PUM2, pumilio RNA binding family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PUM2, pumilio RNA binding family member 2
Synonyms

PUMH2, PUML2
Links

HGNC:14958

NCBI Gene ID: 23369

neXtProt AC: NX_Q8TB72

UniProt: Q8TB72
Chr Location

2p24.1; chr2:20248691-20352253 (-) GRCh38

MGI Vertebrate Homology

Pum2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PUM2
Gene Tree

Pum2

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

109
Endonuclease-mediated

5
Gene trapped

97
Targeted

6
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

104 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit significantly smaller testes and seminiferous tubule degeneration but are otherwise viable and fertile.

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All GO Annotations

58
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

847
Tissues

57
cDNA Data

15
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pum2

ZFIN pum2

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All Sequences

159
RefSeq

77
UniProt

10
CCDS

CCDS25802.1, CCDS49025.1, CCDS49026.1, CCDS79105.1

Ensembl

ENSMUSG00000020594 (Evidence)
NCBI Gene

80913

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020594	Ensembl Gene Model \| MGI Sequence Detail	78448	C57BL/6J	± kb
transcript	ENSMUST00000163569	Ensembl \| MGI Sequence Detail	3560	Not Applicable
polypeptide	ENSMUSP00000131074	Ensembl \| MGI Sequence Detail	1066	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000013493 pumilio homolog 2

(term hierarchy)
PDB

3GVO, 3GVT
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR033133 Pumilio homology domain

IPR033712 Pumilio, RNA binding domain

IPR001313 Pumilio RNA-binding repeat
GlyGen

Q80U58 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 19

cDNA 15

Primer pair 4

Microarray probesets 7

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MGI:1917881

Summaries

All 76

Developmental Gene Expression 19

Gene Ontology 13

Phenotypes 28
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pum2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112728	Chr12:8724129-8724150 (+)	6 bp
Tssr112729	Chr12:8724235-8724275 (+)	121 bp
Tssr112730	Chr12:8724345-8724382 (+)	230 bp
Tssr112731	Chr12:8724391-8724421 (+)	272 bp
Tssr112732	Chr12:8724429-8724450 (+)	306 bp
Tssr112733	Chr12:8724701-8724746 (+)	590 bp
Tssr112734	Chr12:8750365-8750370 (+)	26,234 bp
Tssr112735	Chr12:8762988-8762993 (+)	38,857 bp
Tssr112736	Chr12:8789677-8789704 (+)	65,557 bp
Tssr112737	Chr12:8800115-8800153 (+)	76,000 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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