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Ckap2 Gene Detail
Summary
  • Symbol
    Ckap2
  • Name
    cytoskeleton associated protein 2
  • Synonyms
    LB1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931797
    NCBI Gene: 80986
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:22658176-22675835 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.13 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    556 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931797
 protein coding gene Chr8:22658168-22675835 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033446
 protein coding gene Chr8:20011935-20030363 (-)
A/J MGP_AJ_G0033426
 protein coding gene Chr8:19358210-19375872 (-)
AKR/J MGP_AKRJ_G0033351
 protein coding gene Chr8:19989218-20006902 (-)
BALB/cJ MGP_BALBcJ_G0033422
 protein coding gene Chr8:19482528-19500171 (-)
C3H/HeJ MGP_C3HHeJ_G0033136
 protein coding gene Chr8:20186032-20207486 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033938
 protein coding gene Chr8:20857931-20875596 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030894
 protein coding gene Chr8:16692167-16709466 (-)
CAST/EiJ MGP_CASTEiJ_G0032462
 protein coding gene Chr8:19610132-19630133 (-)
CBA/J MGP_CBAJ_G0033111
 protein coding gene Chr8:21678801-21699472 (-)
DBA/2J MGP_DBA2J_G0033266
 protein coding gene Chr8:19328120-19345784 (-)
FVB/NJ MGP_FVBNJ_G0033210
 protein coding gene Chr8:19127721-19146003 (-)
LP/J MGP_LPJ_G0033355
 protein coding gene Chr8:20009037-20026720 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033253
 protein coding gene Chr8:21288192-21309187 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033957
 protein coding gene Chr8:19887410-19906275 (-)
PWK/PhJ MGP_PWKPhJ_G0032174
 protein coding gene Chr8:18916584-18934465 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032007
 protein coding gene Chr8:19278696-19298817 (-)
WSB/EiJ MGP_WSBEiJ_G0032578
 protein coding gene Chr8:20093838-20116918 (-)



Homology
more
  • Human Ortholog
    CKAP2, cytoskeleton associated protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CKAP2, cytoskeleton associated protein 2
  • Synonyms
    LB1, se20-10, TMAP
  • Links
    NCBI Gene ID: 26586
    neXtProt AC: NX_Q8WWK9
    UniProt: Q8WWK9

  • Chr Location
    13q14.3; chr13:52455429-52476628 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    9
  • cDNA Data
    129
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037725 Ensembl Gene Model | MGI Sequence Detail 17660 C57BL/6J ±  kb
transcript ENSMUST00000046916 Ensembl | MGI Sequence Detail 2593 Not Applicable  
polypeptide ENSMUSP00000039518 Ensembl | MGI Sequence Detail 664 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005509 cytoskeleton-associated protein 2
    (term hierarchy)
  • InterPro Domains
    IPR029197 Cytoskeleton-associated protein 2, C-terminal
    IPR026165 Cytoskeleton-associated protein 2 family
  • GlyGen
    Q3V1H1 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 129
    cDNA 129

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142556, MGI:2142779
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:67729 Udina IG, et al., [Evolutionarily-conserved gene CKAP2,located in region 13q14.3 of the human genome, is frequently rearranged in various tumors]. Genetika. 2001 Jan;37(1):120-3
  • Latest
    J:344805 McAlear TS, et al., The mitotic spindle protein CKAP2 potently increases formation and stability of microtubules. Elife. 2022 Jan 14;11
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory