Sle1c QTL Detail

Summary

• Symbol
  Sle1c
• Name
  systematic lupus erythematosus susceptibility 1c

• Feature Type
  QTL
• IDs
  MGI:1931844
  NCBI Gene: 112377
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Chr1:188594514-189303617 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 94.73 cM (cM position of peak correlated region/marker)
• Mapping Data
  3 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 3 alleles in 2 genetic backgrounds
  3 phenotype references
  

• All Mutations and Alleles
  3
• QTL
  3
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  112377

References

• Summaries
  All 7

  Phenotypes 3
• Earliest
  J:67544 Morel L, et al., The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1787-92
• Latest
  J:251662 Orme JJ, et al., Leukocyte Beta-Catenin Expression Is Disturbed in Systemic Lupus Erythematosus. PLoS One. 2016;11(8):e0161682

Candidate Genes for Sle1c:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Cr2	Chr1:194819119-194859024 (-)	J:73128	The NZM2410 interval contains the Sle1 QTLs and originated from an (NZB x NZW) cross. In order to construct congenic strains of mice which contain selected Sle loci, NZM2410 were backcrossed to C57BL/6J mice six successive times, screening progeny withPCR or SSR markers for specific genomic intervals. One such locus Sle1c resided in an interval of mouse Chromosome 1 that contained Cr2 which is a possible candidate for Sle1c. There were at least 16 nucleotide sequence differences between NZW and C57BL/6J at the Cr2 locus. The authors provided evidence suggesting that Cr2 is the disease susceptibility gene corresponding to the Sle1c QTL.