Zbtb22 MGI Mouse Gene Detail - MGI:1931870 - zinc finger and BTB domain containing 22

Symbol

Zbtb22
Name

zinc finger and BTB domain containing 22
Synonyms

1110008J20Rik, Bing1, Zfp297

Feature Type

protein coding gene
IDs

MGI:1931870
NCBI Gene: 81630
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:34135150-34138299 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 17.98 cM
Mapping Data

3 experiments

Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931870	protein coding gene	Chr17:34134878-34138299 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023543	protein coding gene	Chr17:33865170-33868458 (+)
A/J	MGP_AJ_G0023504	protein coding gene	Chr17:32698425-32701840 (+)
AKR/J	MGP_AKRJ_G0023470	protein coding gene	Chr17:33094082-33097497 (+)
BALB/cJ	MGP_BALBcJ_G0023507	protein coding gene	Chr17:32871380-32875017 (+)
C3H/HeJ	MGP_C3HHeJ_G0023269	protein coding gene	Chr17:33449440-33452821 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023948	protein coding gene	Chr17:35119525-35122032 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021423	protein coding gene	Chr17:30200617-30204017 (+)
CAST/EiJ	MGP_CASTEiJ_G0022771	protein coding gene	Chr17:33520589-33525865 (+)
CBA/J	MGP_CBAJ_G0023246	protein coding gene	Chr17:36547521-36550876 (+)
DBA/2J	MGP_DBA2J_G0023374	protein coding gene	Chr17:32076002-32079533 (+)
FVB/NJ	MGP_FVBNJ_G0023343	protein coding gene	Chr17:31935264-31938681 (+)
LP/J	MGP_LPJ_G0023452	protein coding gene	Chr17:34139895-34144156 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023365	protein coding gene	Chr17:35599913-35603331 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023990	protein coding gene	Chr17:33420160-33425633 (+)
PWK/PhJ	MGP_PWKPhJ_G0022519	protein coding gene	Chr17:30989216-30992853 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022335	protein coding gene	Chr17:31382331-31385741 (+)
WSB/EiJ	MGP_WSBEiJ_G0022831	protein coding gene	Chr17:33460202-33463517 (+)

Human Ortholog

ZBTB22, zinc finger and BTB domain containing 22

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZBTB22, zinc finger and BTB domain containing 22
Synonyms

BING1, fru, fruitless, ZBTB22A, ZNF297, ZNF297A
Links

HGNC:13085

NCBI Gene ID: 9278

neXtProt AC: NX_O15209

UniProt: O15209
Chr Location

6p21.32; chr6:33314406-33317942 (-) GRCh38

MGI Vertebrate Homology

Zbtb22 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ZBTB22
Gene Tree

Zbtb22

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

2
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show protection from high-fat diet induced obesity, showing improved energy expenditure, glucose tolerance, and insulin sensitivity and reduced hepatic steatosis.

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

750
Tissues

40
cDNA Data

64
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zbtb22

ZFIN zbtb22a, zbtb22b

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All Sequences

46
RefSeq

2
UniProt

5
CCDS

CCDS28634.1

Ensembl

ENSMUSG00000051390 (Evidence)
NCBI Gene

81630

			Length	Strain/Species	Flank
genomic	81630	NCBI Gene Model \| MGI Sequence Detail	3150	C57BL/6J	± kb
transcript	NM_020625	RefSeq \| MGI Sequence Detail	2680	Not Specified
polypeptide	Q9Z0G7	UniProt \| EBI \| MGI Sequence Detail	638	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017569 zinc finger and BTB domain-containing protein 22

(term hierarchy)
InterPro Domains

IPR000210 BTB/POZ domain

IPR011333 SKP1/BTB/POZ domain superfamily

IPR050457 Zinc finger and BTB domain-containing

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 67

Genomic 1

cDNA 64

Primer pair 2

Microarray probesets 4

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MGI:1920984, MGI:2146815, MGI:2146842

Summaries

All 38

Developmental Gene Expression 7

Gene Ontology 5

Phenotypes 3
Earliest

J:63110 Allcock RJ, et al., The mouse as a model for the effects of MHC genes on human disease. Immunol Today. 2000 Jul;21(7):328-32
Latest

J:344976 Liu N, et al., Hepatic ZBTB22 promotes hyperglycemia and insulin resistance via PEPCK1-driven gluconeogenesis. EMBO Rep. 2023 Jun 5;24(6):e56390

TSS for Zbtb22:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143820	Chr17:34134879-34134890 (+)	-265 bp
Tssr143821	Chr17:34135156-34135170 (+)	13 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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