Dnajb1 MGI Mouse Gene Detail - MGI:1931874 - DnaJ heat shock protein family (Hsp40) member B1

Symbol

Dnajb1
Name

DnaJ heat shock protein family (Hsp40) member B1
Synonyms

0610007I11Rik, Hsp40

Feature Type

protein coding gene
IDs

MGI:1931874
NCBI Gene: 81489
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr8:84334822-84339282 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 40.22 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

182 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931874	protein coding gene	Chr8:84334804-84339282 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033835	protein coding gene	Chr8:84441966-84445719 (+)
A/J	MGP_AJ_G0033818	protein coding gene	Chr8:81146676-81150425 (+)
AKR/J	MGP_AKRJ_G0033744	protein coding gene	Chr8:83534295-83538048 (+)
BALB/cJ	MGP_BALBcJ_G0033811	protein coding gene	Chr8:81243054-81246807 (+)
C3H/HeJ	MGP_C3HHeJ_G0033521	protein coding gene	Chr8:84161421-84165170 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034331	protein coding gene	Chr8:87667947-87671674 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031273	protein coding gene	Chr8:74928281-74932002 (+)
CAST/EiJ	MGP_CASTEiJ_G0032851	protein coding gene	Chr8:83551149-83555205 (+)
CBA/J	MGP_CBAJ_G0033499	protein coding gene	Chr8:90815688-90819666 (+)
DBA/2J	MGP_DBA2J_G0033652	protein coding gene	Chr8:80785993-80789742 (+)
FVB/NJ	MGP_FVBNJ_G0033598	protein coding gene	Chr8:79697559-79701276 (+)
LP/J	MGP_LPJ_G0033742	protein coding gene	Chr8:84556102-84559855 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033640	protein coding gene	Chr8:93312448-93316211 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034348	protein coding gene	Chr8:83508802-83512529 (+)
PWK/PhJ	MGP_PWKPhJ_G0032555	protein coding gene	Chr8:79999356-80003128 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032392	protein coding gene	Chr8:82305520-82309264 (+)
WSB/EiJ	MGP_WSBEiJ_G0032964	protein coding gene	Chr8:83913824-83918591 (+)

Human Ortholog

DNAJB1, DnaJ heat shock protein family (Hsp40) member B1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJB1, DnaJ heat shock protein family (Hsp40) member B1
Synonyms

Hdj1, Hsp40, HSPF1, RSPH16B, Sis1
Links

HGNC:5270

NCBI Gene ID: 3337

neXtProt AC: NX_P25685

UniProt: P25685
Chr Location

19p13.12; chr19:14514769-14560391 (-) GRCh38

MGI Vertebrate Homology

Dnajb1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DNAJB1
Gene Tree

Dnajb1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
39 phenotype references

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Dnajb1
Incidental Mutations

CvDC
Find Mice (IMSR)

21 strains or lines available

Mice homozygous for a knock-out allele are viable, fertile, and overtly normal; however, homozygous null peritoneal macrophages display impaired thermotolerance in the early (but not in the late) phase after mild heat treatment.

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All GO Annotations

43
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

754
Tissues

38
cDNA Data

16
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnajb1

ZFIN dnajb1a, dnajb1b

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All Sequences

59
RefSeq

4
UniProt

4
CCDS

CCDS22456.1, CCDS85571.1

Ensembl

ENSMUSG00000005483 (Evidence)
NCBI Gene

81489

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005483	Ensembl Gene Model \| MGI Sequence Detail	4461	C57BL/6J	± kb
transcript	ENSMUST00000005620	Ensembl \| MGI Sequence Detail	2996	Not Applicable
polypeptide	ENSMUSP00000005620	Ensembl \| MGI Sequence Detail	340	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006573 DnaJ homolog subfamily B member 1

(term hierarchy)
InterPro Domains

IPR002939 Chaperone DnaJ, C-terminal

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR018253 DnaJ domain, conserved site

IPR051339 DnaJ homolog subfamily B

IPR008971 HSP40/DnaJ peptide-binding
GlyGen

Q9QYJ3 1 site, 1 O-linked glycan (1 site)

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All nucleic 17

cDNA 16

Primer pair 1

Microarray probesets 4

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MGI:1915569

Summaries

All 81

Developmental Gene Expression 5

Gene Ontology 9

Phenotypes 39
Earliest

J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
Latest

J:348117 Okuma H, et al., N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on alpha-dystroglycan and prevents muscular dystrophy. Elife. 2023 Feb 1;12

TSS for Dnajb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78269	Chr8:84334805-84334827 (+)	-6 bp
Tssr2617	Chr8:84334843-84334854 (+)	27 bp
Tssr78270	Chr8:84334855-84334909 (+)	60 bp
Tssr78271	Chr8:84334918-84334937 (+)	106 bp
Tssr78272	Chr8:84335138-84335149 (+)	322 bp
Tssr78273	Chr8:84335165-84335173 (+)	347 bp
Tssr78274	Chr8:84335177-84335204 (+)	369 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24