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Btnl4 Gene Detail
Summary
  • Symbol
    Btnl4
  • Name
    butyrophilin-like 4
  • Synonyms
    Btn3a3, EG632126, NG11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932036
    NCBI Gene: 632126
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34687320-34696402 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932036
 protein coding gene Chr17:34685536-34696402 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023574
 protein coding gene Chr17:34503524-34609150 (-)
A/J MGP_AJ_G0023536
 protein coding gene Chr17:33318281-33325178 (-)
AKR/J MGP_AKRJ_G0023501
 protein coding gene Chr17:33707766-33719227 (-)
BALB/cJ MGP_BALBcJ_G0023541
 protein coding gene Chr17:33468684-33475586 (-)
C3H/HeJ MGP_C3HHeJ_G0023300
 protein coding gene Chr17:34065828-34073014 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023980
 protein coding gene Chr17:35787109-35794004 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021460
 protein coding gene Chr17:31313209-31330164 (-)
CAST/EiJ MGP_CASTEiJ_G0022800
 protein coding gene Chr17:34212273-34219269 (-)
CBA/J MGP_CBAJ_G0023278
 protein coding gene Chr17:37245073-37251529 (-)
DBA/2J MGP_DBA2J_G0023407
 protein coding gene Chr17:32651510-32658476 (-)
FVB/NJ MGP_FVBNJ_G0023373
 protein coding gene Chr17:32514359-32526135 (-)
LP/J MGP_LPJ_G0023484
 protein coding gene Chr17:34755165-34762049 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023396
 protein coding gene Chr17:36204093-36250544 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024023
 protein coding gene Chr17:34033382-34040294 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0022366
 protein coding gene Chr17:32048793-32057279 (-)
WSB/EiJ MGP_WSBEiJ_G0022861
 protein coding gene Chr17:34117350-34126755 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal intraepithelial T cell numbers in the gut.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 632126 NCBI Gene Model | MGI Sequence Detail 9083 C57BL/6J ±  kb
    transcript NM_030746 RefSeq | MGI Sequence Detail 2802 ZRU/MplStud  
    polypeptide NP_109671 RefSeq | MGI Sequence Detail 586 ZRU/MplStud  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less

    • Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:3648221
    References
    more
    • Summaries
      All 17
      Gene Ontology 1
      Phenotypes 8
    • Earliest
      J:61935 Stammers M, et al., BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse. Immunogenetics. 2000 Apr;51(4-5):373-82
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory