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Agpat1 Gene Detail
Summary
  • Symbol
    Agpat1
  • Name
    1-acylglycerol-3-phosphate O-acyltransferase 1
  • Synonyms
    1-AGP, Lpaat-alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932075
    NCBI Gene: 55979
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34823236-34832423 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932075
 protein coding gene Chr17:34823164-34832423 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023581
 protein coding gene Chr17:34682995-34692201 (+)
A/J MGP_AJ_G0023543
 protein coding gene Chr17:33502601-33511797 (+)
AKR/J MGP_AKRJ_G0023508
 protein coding gene Chr17:33919158-33928346 (+)
BALB/cJ MGP_BALBcJ_G0023547
 protein coding gene Chr17:33650018-33659220 (+)
C3H/HeJ MGP_C3HHeJ_G0023307
 protein coding gene Chr17:34313516-34322726 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023987
 protein coding gene Chr17:35998702-36007886 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021466
 protein coding gene Chr17:31390709-31399794 (+)
CAST/EiJ MGP_CASTEiJ_G0022807
 protein coding gene Chr17:34385223-34394445 (+)
CBA/J MGP_CBAJ_G0023285
 protein coding gene Chr17:37532621-37541829 (+)
DBA/2J MGP_DBA2J_G0023413
 protein coding gene Chr17:32792541-32801727 (+)
FVB/NJ MGP_FVBNJ_G0023380
 protein coding gene Chr17:32695277-32704265 (+)
LP/J MGP_LPJ_G0023491
 protein coding gene Chr17:34954080-34963338 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023403
 protein coding gene Chr17:36418489-36427673 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024030
 protein coding gene Chr17:34229779-34238999 (+)
PWK/PhJ MGP_PWKPhJ_G0022555
 protein coding gene Chr17:31721442-31730720 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022372
 protein coding gene Chr17:32214585-32223749 (+)
WSB/EiJ MGP_WSBEiJ_G0022868
 protein coding gene Chr17:34317864-34330336 (+)



Homology
more
  • Human Ortholog
    AGPAT1, 1-acylglycerol-3-phosphate O-acyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGPAT1, 1-acylglycerol-3-phosphate O-acyltransferase 1
  • Synonyms
    1-AGPAT1, G15, LPAATA, LPAAT-alpha, LPLAT1
  • Links
    NCBI Gene ID: 10554
    neXtProt AC: NX_Q99943
    UniProt: Q99943

  • Chr Location
    6p21.32; chr6:32168212-32178108 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show postnatal and premature death, reduced body weight and total body fat, decreased plasma leptin, glucose and IGF-1 levels, reduced gluconeogenesis, infertility, arrest of male meiosis, ovulation and estrous cycle anomalies, hyperactivity and audiogenic seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    48
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034254 Ensembl Gene Model | MGI Sequence Detail 9188 C57BL/6J ±  kb
    transcript ENSMUST00000037489 Ensembl | MGI Sequence Detail 2190 Not Applicable  
    polypeptide ENSMUSP00000048573 Ensembl | MGI Sequence Detail 285 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000003834 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
      (term hierarchy)
    • EC
      2.3.1.51
    • InterPro Domains
      IPR004552 1-acyl-sn-glycerol-3-phosphate acyltransferase
      IPR002123 Phospholipid/glycerol acyltransferase
    • GlyGen
      O35083 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 1
      cDNA 7
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2147034
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:43215 Kume K, et al., cDNA cloning and expression of murine 1-acyl-sn-glycerol-3-phosphate acyltransferase. Biochem Biophys Res Commun. 1997 Aug 28;237(3):663-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory