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Egfl8 Gene Detail
Summary
  • Symbol
    Egfl8
  • Name
    EGF-like domain 8
  • Synonyms
    NG3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932094
    NCBI Gene: 81701
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34832323-34834945 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.19 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932094
 protein coding gene Chr17:34832174-34835536 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023582
 protein coding gene Chr17:34692101-34694723 (-)
A/J MGP_AJ_G0023544
 protein coding gene Chr17:33511697-33514319 (-)
AKR/J MGP_AKRJ_G0023509
 protein coding gene Chr17:33928246-33930868 (-)
BALB/cJ MGP_BALBcJ_G0023548
 protein coding gene Chr17:33659120-33661743 (-)
C3H/HeJ MGP_C3HHeJ_G0023308
 protein coding gene Chr17:34322626-34325248 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023988
 protein coding gene Chr17:36007786-36010408 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021467
 protein coding gene Chr17:31399694-31402275 (-)
CAST/EiJ MGP_CASTEiJ_G0022808
 protein coding gene Chr17:34394345-34396966 (-)
CBA/J MGP_CBAJ_G0023286
 protein coding gene Chr17:37541729-37544351 (-)
DBA/2J MGP_DBA2J_G0023414
 protein coding gene Chr17:32801627-32804250 (-)
FVB/NJ MGP_FVBNJ_G0023381
 protein coding gene Chr17:32705529-32708148 (-)
LP/J MGP_LPJ_G0023492
 protein coding gene Chr17:34963238-34965860 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023404
 protein coding gene Chr17:36427573-36430197 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024031
 protein coding gene Chr17:34238899-34241520 (-)
PWK/PhJ MGP_PWKPhJ_G0022556
 protein coding gene Chr17:31730620-31733239 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022373
 protein coding gene Chr17:32223649-32226404 (-)
WSB/EiJ MGP_WSBEiJ_G0022869
 protein coding gene Chr17:34330236-34332857 (-)



Homology
more
  • Human Ortholog
    EGFL8, EGF like domain multiple 8
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EGFL8, EGF like domain multiple 8
  • Synonyms
    C6orf8, NG3
  • Links
    NCBI Gene ID: 80864
    neXtProt AC: NX_Q99944
    UniProt: Q99944

  • Chr Location
    6p21.32; chr6:32164595-32168281 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show no notable phenotype in a high-throughput phenotype screen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    26
  • cDNA Data
    5
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015467 Ensembl Gene Model | MGI Sequence Detail 2623 C57BL/6J ±  kb
    transcript ENSMUST00000015611 Ensembl | MGI Sequence Detail 1150 Not Applicable  
    polypeptide ENSMUSP00000015611 Ensembl | MGI Sequence Detail 293 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      Genomic 1
      cDNA 5
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:63109 Yung Yu C, et al., The human and mouse MHC class III region: a parade of 21 genes at the centromeric segment. Immunol Today. 2000 Jul;21(7):320-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory