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Oga Gene Detail
Summary
  • Symbol
    Oga
  • Name
    O-GlcNAcase
  • Synonyms
    2810009A20Rik, 4833427O07Rik, 5830447M11Rik, Hy5, Mgea5, mKIAA0679
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932139
    NCBI Gene: 76055
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:45738698-45772274 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 38.75 cM, cytoband D1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    721 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932139
 protein coding gene Chr19:45738698-45772276 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025193
 protein coding gene Chr19:45372906-45406578 (-)
A/J MGP_AJ_G0025169
 protein coding gene Chr19:43154393-43187329 (-)
AKR/J MGP_AKRJ_G0025138
 protein coding gene Chr19:44543328-44576304 (-)
BALB/cJ MGP_BALBcJ_G0025164
 protein coding gene Chr19:43213064-43246060 (-)
C3H/HeJ MGP_C3HHeJ_G0024924
 protein coding gene Chr19:44721542-44754537 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025607
 protein coding gene Chr19:46505666-46538628 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023021
 protein coding gene Chr19:42398989-42433211 (-)
CAST/EiJ MGP_CASTEiJ_G0024389
 protein coding gene Chr19:44474589-44507865 (-)
CBA/J MGP_CBAJ_G0024904
 protein coding gene Chr19:48842111-48878243 (-)
DBA/2J MGP_DBA2J_G0025036
 protein coding gene Chr19:42962876-42996482 (-)
FVB/NJ MGP_FVBNJ_G0024997
 protein coding gene Chr19:42755963-42788665 (-)
LP/J MGP_LPJ_G0025122
 protein coding gene Chr19:45286696-45319540 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025028
 protein coding gene Chr19:48170864-48204148 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025664
 protein coding gene Chr19:44624283-44673169 (-)
PWK/PhJ MGP_PWKPhJ_G0024138
 protein coding gene Chr19:42896150-42929930 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023942
 protein coding gene Chr19:43317345-43350625 (-)
WSB/EiJ MGP_WSBEiJ_G0024459
 protein coding gene Chr19:44787485-44821863 (-)



Homology
more
  • Human Ortholog
    OGA, O-GlcNAcase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OGA, O-GlcNAcase
  • Synonyms
    MEA5, MGEA5, NCOAT
  • Links
    NCBI Gene ID: 10724
    neXtProt AC: NX_O60502
    UniProt: O60502

  • Chr Location
    10q24.32; chr10:101784443-101818465 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele exhibit perinatal lethality associated with a developmental delay and respiratory failure. Mouse embryonic fibroblasts exhibit proliferative and mitotic defects, frequent cytokinesis failure, and loss of genomic stability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    21
  • cDNA Data
    12
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76055 NCBI Gene Model | MGI Sequence Detail 33577 C57BL/6J ±  kb
    transcript NM_023799 RefSeq | MGI Sequence Detail 5048 ZRU/MplStud  
    polypeptide Q9EQQ9 UniProt | EBI | MGI Sequence Detail 916 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 23
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1919887, MGI:1921158, MGI:1923305, MGI:2147432, MGI:6276298
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 21
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:354044 Cabrera JT, et al., Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low-dose streptozotocin-induced type 2 diabetic mice. Diab Vasc Dis Res. 2023 May-Jun;20(3):14791641231173630
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory