Plekha3 MGI Mouse Gene Detail - MGI:1932515 - pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3

Symbol

Plekha3
Name

pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3
Synonyms

FAPP1

Feature Type

protein coding gene
IDs

MGI:1932515
NCBI Gene: 83435
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:76505625-76527172 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 45.10 cM, cytoband D
Mapping Data

2 experiments

SNPs within 2kb

660 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932515	protein coding gene	Chr2:76505436-76527679 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025869	protein coding gene	Chr2:77071056-77092634 (+)
A/J	MGP_AJ_G0025846	protein coding gene	Chr2:74082365-74103895 (+)
AKR/J	MGP_AKRJ_G0025815	protein coding gene	Chr2:76075488-76096790 (+)
BALB/cJ	MGP_BALBcJ_G0025841	protein coding gene	Chr2:74257142-74278678 (+)
C3H/HeJ	MGP_C3HHeJ_G0025601	protein coding gene	Chr2:76278274-76300275 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026288	protein coding gene	Chr2:79357468-79378989 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023691	protein coding gene	Chr2:71486212-71507881 (+)
CAST/EiJ	MGP_CASTEiJ_G0025063	protein coding gene	Chr2:76616544-76637954 (+)
CBA/J	MGP_CBAJ_G0025582	protein coding gene	Chr2:82293025-82314555 (+)
DBA/2J	MGP_DBA2J_G0025713	protein coding gene	Chr2:73670753-73692333 (+)
FVB/NJ	MGP_FVBNJ_G0025675	protein coding gene	Chr2:73067109-73089047 (+)
LP/J	MGP_LPJ_G0025801	protein coding gene	Chr2:76954017-76975584 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025706	protein coding gene	Chr2:84114336-84135843 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026344	protein coding gene	Chr2:76200177-76221698 (+)
PWK/PhJ	MGP_PWKPhJ_G0024806	protein coding gene	Chr2:73633856-73655643 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024612	protein coding gene	Chr2:76448740-76470329 (+)
WSB/EiJ	MGP_WSBEiJ_G0025132	protein coding gene	Chr2:76668871-76689331 (+)

Human Ortholog

PLEKHA3, pleckstrin homology domain containing A3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLEKHA3, pleckstrin homology domain containing A3
Synonyms

FAPP1
Links

HGNC:14338

NCBI Gene ID: 65977

neXtProt AC: NX_Q9HB20

UniProt: Q9HB20
Chr Location

2q31.2; chr2:178480457-178516463 (+) GRCh38

MGI Vertebrate Homology

Plekha3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLEKHA3
Gene Tree

Plekha3

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

7
Targeted

6
Genomic Mutations

3 involving Plekha3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

836
Tissues

44
cDNA Data

4
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plekha3

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All Sequences

36
RefSeq

4
UniProt

1
CCDS

CCDS16162.1

Ensembl

ENSMUSG00000002733 (Evidence)
NCBI Gene

83435

			Length	Strain/Species	Flank
genomic	ENSMUSG00000002733	Ensembl Gene Model \| MGI Sequence Detail	21548	C57BL/6J	± kb
transcript	ENSMUST00000111920	Ensembl \| MGI Sequence Detail	2534	Not Applicable
polypeptide	ENSMUSP00000107551	Ensembl \| MGI Sequence Detail	297	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000012855 pleckstrin homology domain-containing family A member 3

(term hierarchy)
InterPro Domains

IPR045188 PH domain containing protein Boi1/Boi2-like

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

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All nucleic 4

cDNA 4

Microarray probesets 4

Summaries

All 36

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 13
Earliest

J:65271 Dowler S, et al., Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J. 2000 Oct 1;351(Pt 1):19-31
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Plekha3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18501	Chr2:76505609-76505631 (+)	-5 bp
Tssr18502	Chr2:76505634-76505665 (+)	25 bp
Tssr18503	Chr2:76505666-76505693 (+)	55 bp
Tssr18505	Chr2:76518425-76518442 (+)	12,809 bp
Tssr18506	Chr2:76522763-76522768 (+)	17,141 bp
Tssr18507	Chr2:76526160-76526179 (+)	20,545 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24