Cstf2t MGI Mouse Gene Detail - MGI:1932622 - cleavage stimulation factor, 3' pre-RNA subunit 2, tau

Symbol

Cstf2t
Name

cleavage stimulation factor, 3' pre-RNA subunit 2, tau
Synonyms

64kDa, tCstF-64

Feature Type

protein coding gene
IDs

MGI:1932622
NCBI Gene: 83410
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:31060241-31063992 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 25.94 cM
Mapping Data

3 experiments

SNPs within 2kb

141 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932622	protein coding gene	Chr19:31060237-31064469 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025036	protein coding gene	Chr19:29652768-29656527 (+)
A/J	MGP_AJ_G0025013	protein coding gene	Chr19:28164816-28168565 (+)
AKR/J	MGP_AKRJ_G0024981	protein coding gene	Chr19:29160886-29164635 (+)
BALB/cJ	MGP_BALBcJ_G0025012	protein coding gene	Chr19:28215826-28219575 (+)
C3H/HeJ	MGP_C3HHeJ_G0024768	protein coding gene	Chr19:29149324-29153073 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025453	protein coding gene	Chr19:30468867-30472616 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022872	protein coding gene	Chr19:28121180-28124899 (+)
CAST/EiJ	MGP_CASTEiJ_G0024238	protein coding gene	Chr19:29021792-29025554 (+)
CBA/J	MGP_CBAJ_G0024746	protein coding gene	Chr19:31910527-31914276 (+)
DBA/2J	MGP_DBA2J_G0024878	protein coding gene	Chr19:28102576-28106325 (+)
FVB/NJ	MGP_FVBNJ_G0024840	protein coding gene	Chr19:27932392-27936151 (+)
LP/J	MGP_LPJ_G0024963	protein coding gene	Chr19:29655222-29658981 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024867	protein coding gene	Chr19:31803617-31807366 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025508	protein coding gene	Chr19:29183542-29187291 (+)
PWK/PhJ	MGP_PWKPhJ_G0023986	protein coding gene	Chr19:27784406-27788136 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023790	protein coding gene	Chr19:28531211-28534783 (+)
WSB/EiJ	MGP_WSBEiJ_G0024305	protein coding gene	Chr19:29249470-29253219 (+)

Human Ortholog

CSTF2T, cleavage stimulation factor subunit 2 tau variant

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CSTF2T, cleavage stimulation factor subunit 2 tau variant
Synonyms

CstF-64T
Links

HGNC:17086

NCBI Gene ID: 23283

neXtProt AC: NX_Q9H0L4

UniProt: Q9H0L4
Chr Location

10q21.1; chr10:51695486-51699595 (-) GRCh38

MGI Vertebrate Homology

Cstf2t stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CSTF2T
Gene Tree

Cstf2t

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
2 images
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a targeted null allele are infertile due to low sperm counts, significant developmental defects in spermiogenesis, and variable abnormalities in epididymal sperm morphology and motility consistent with oligoasthenoteratozoospermia. Homozygous null females are fertile.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

738
Tissues

4
cDNA Data

97
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

2
UniProt

1
CCDS

CCDS37958.1

Ensembl

ENSMUSG00000053536 (Evidence)
NCBI Gene

83410

			Length	Strain/Species	Flank
genomic	83410	NCBI Gene Model \| MGI Sequence Detail	3752	C57BL/6J	± kb
transcript	NM_031249	RefSeq \| MGI Sequence Detail	3764	C57BL/6
polypeptide	Q8C7E9	UniProt \| EBI \| MGI Sequence Detail	632	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005977 cleavage stimulation factor subunit 2 tau variant

(term hierarchy)
InterPro Domains

IPR025742 Cleavage stimulation factor subunit 2, hinge domain

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR026896 Transcription termination and cleavage factor, C-terminal domain

IPR038192 Transcription termination and cleavage factor, C-terminal domain superfamily

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All nucleic 98

cDNA 97

Primer pair 1

Microarray probesets 4

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MGI:2147783

Summaries

All 33

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 8
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:316534 Grozdanov PN, et al., Cstf2t Regulates expression of histones and histone-like proteins in male germ cells. Andrology. 2018 Jul;6(4):605-615

TSS for Cstf2t:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155933	Chr19:31060282-31060302 (+)	51 bp
Tssr155934	Chr19:31060382-31060446 (+)	173 bp
Tssr155935	Chr19:31062945-31062949 (+)	2,706 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24