Pgam2 MGI Mouse Gene Detail - MGI:1933118 - phosphoglycerate mutase 2

Symbol

Pgam2
Name

phosphoglycerate mutase 2

Feature Type

protein coding gene
IDs

MGI:1933118
NCBI Gene: 56012
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:5751640-5753733 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 3.87 cM
Mapping Data

2 experiments

SNPs within 2kb

145 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933118	protein coding gene	Chr11:5751637-5753796 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018007	protein coding gene	Chr11:2884575-2886667 (-)
A/J	MGP_AJ_G0017980	protein coding gene	Chr11:2770759-2772851 (-)
AKR/J	MGP_AKRJ_G0017944	protein coding gene	Chr11:2911813-2913905 (-)
BALB/cJ	MGP_BALBcJ_G0017948	protein coding gene	Chr11:2761990-2764082 (-)
C3H/HeJ	MGP_C3HHeJ_G0017761	protein coding gene	Chr11:2790896-2792989 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018400	protein coding gene	Chr11:2962245-2964338 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016058	protein coding gene	Chr11:2654949-2657048 (-)
CAST/EiJ	MGP_CASTEiJ_G0017323	protein coding gene	Chr11:2754551-2756643 (-)
CBA/J	MGP_CBAJ_G0017736	protein coding gene	Chr11:3309809-3311902 (-)
DBA/2J	MGP_DBA2J_G0017846	protein coding gene	Chr11:2677116-2679209 (-)
FVB/NJ	MGP_FVBNJ_G0017838	protein coding gene	Chr11:2705816-2707909 (-)
LP/J	MGP_LPJ_G0017917	protein coding gene	Chr11:2963492-2965584 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017864	protein coding gene	Chr11:2927743-2929835 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018440	protein coding gene	Chr11:2917343-2919436 (-)
PWK/PhJ	MGP_PWKPhJ_G0017103	protein coding gene	Chr11:2700545-2702637 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016900	protein coding gene	Chr11:2883262-2885355 (-)
WSB/EiJ	MGP_WSBEiJ_G0017377	protein coding gene	Chr11:2762655-2764747 (-)

Human Ortholog

PGAM2, phosphoglycerate mutase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PGAM2, phosphoglycerate mutase 2
Synonyms

GSD10, PGAM-M, PGAMM
Links

HGNC:8889

NCBI Gene ID: 5224

neXtProt AC: NX_P15259

UniProt: P15259
Chr Location

7p13; chr7:44062727-44065567 (-) GRCh38

MGI Vertebrate Homology

Pgam2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PGAM2
Protein SuperFamily

6PFK_2-Ptase
Gene Tree

Pgam2

Diseases

1 with human PGAM2 associations

				Human Disease	Mouse Models
				myoglobinuria IDs myoglobinuria DOID:0080108 MESH:D009212 OMIM:160010 OMIM:268200 OMIM:550500

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Gene trapped

4
Targeted

1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

12 strains or lines available

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All GO Annotations

22
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1100
Tissues

126
cDNA Data

7
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pgam2

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS24404.1

Ensembl

ENSMUSG00000020475 (Evidence)
NCBI Gene

56012

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020475	Ensembl Gene Model \| MGI Sequence Detail	2094	C57BL/6J	± kb
transcript	ENSMUST00000020768	Ensembl \| MGI Sequence Detail	840	Not Applicable
polypeptide	ENSMUSP00000020768	Ensembl \| MGI Sequence Detail	253	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012593 phosphoglycerate mutase 2

(term hierarchy)
EC

5.4.2.11, 5.4.2.4
InterPro Domains

IPR029033 Histidine phosphatase superfamily

IPR013078 Histidine phosphatase superfamily, clade-1

IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site

IPR005952 Phosphoglycerate mutase 1
GlyGen

O70250 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 12

cDNA 7

Primer pair 5

Microarray probesets 4

Summaries

All 54

Developmental Gene Expression 14

Gene Ontology 14

Phenotypes 6
Earliest

J:203034 Fundele R, et al., Developmental activation of phosphoglycerate mutase-2 in the testis of the mouse. Dev Biol. 1987 Dec;124(2):562-6
Latest

J:340570 Bejarano E, et al., Unbalanced redox status network as an early pathological event in congenital cataracts. Redox Biol. 2023 Oct;66:102869

TSS for Pgam2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106646	Chr11:5753735-5753759 (-)	-14 bp
Tssr106645	Chr11:5753706-5753728 (-)	16 bp
Tssr106644	Chr11:5753683-5753689 (-)	47 bp
Tssr106643	Chr11:5753558-5753569 (-)	169 bp
Tssr106642	Chr11:5753319-5753347 (-)	400 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24