Acox3 MGI Mouse Gene Detail - MGI:1933156 - acyl-Coenzyme A oxidase 3, pristanoyl

Symbol

Acox3
Name

acyl-Coenzyme A oxidase 3, pristanoyl
Synonyms

EST-s59, PCOX, pristanoyl-CoA oxidase

Feature Type

protein coding gene
IDs

MGI:1933156
NCBI Gene: 80911
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr5:35740293-35772397 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 18.32 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

1014 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933156	protein coding gene	Chr5:35740293-35772696 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029481	protein coding gene	Chr5:33870799-33908793 (+)
A/J	MGP_AJ_G0029448	protein coding gene	Chr5:32763847-32796110 (+)
AKR/J	MGP_AKRJ_G0029397	protein coding gene	Chr5:34021913-34058357 (+)
BALB/cJ	MGP_BALBcJ_G0029458	protein coding gene	Chr5:33283497-33316273 (+)
C3H/HeJ	MGP_C3HHeJ_G0029180	protein coding gene	Chr5:34039058-34072699 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029912	protein coding gene	Chr5:35784121-35817756 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027149	protein coding gene	Chr5:30527316-30560986 (+)
CAST/EiJ	MGP_CASTEiJ_G0028589	protein coding gene	Chr5:33134532-33168298 (+)
CBA/J	MGP_CBAJ_G0029148	protein coding gene	Chr5:36624115-36663232 (+)
DBA/2J	MGP_DBA2J_G0029296	protein coding gene	Chr5:32914329-32947046 (+)
FVB/NJ	MGP_FVBNJ_G0029255	protein coding gene	Chr5:32380489-32413616 (+)
LP/J	MGP_LPJ_G0029381	protein coding gene	Chr5:34304919-34340667 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029285	protein coding gene	Chr5:37425784-37458042 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029945	protein coding gene	Chr5:33525551-33557702 (+)
PWK/PhJ	MGP_PWKPhJ_G0028314	protein coding gene	Chr5:32077732-32114104 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028145	protein coding gene	Chr5:32979784-33029145 (+)
WSB/EiJ	MGP_WSBEiJ_G0028670	protein coding gene	Chr5:33587882-33620026 (+)

Human Ortholog

ACOX3, acyl-CoA oxidase 3, pristanoyl

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACOX3, acyl-CoA oxidase 3, pristanoyl
Links

HGNC:121

NCBI Gene ID: 8310

neXtProt AC: NX_O15254

UniProt: O15254
Chr Location

4p16.1; chr4:8355305-8440723 (-) GRCh38

MGI Vertebrate Homology

Acox3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACOX3
Protein SuperFamily

Acyl-CoA_oxidase
Gene Tree

Acox3

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

2
Radiation induced

4
Spontaneous

1
Genomic Mutations

8 involving Acox3
Incidental Mutations

APF
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

838
Tissues

127
cDNA Data

32
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acox3

ZFIN acox3

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All Sequences

88
RefSeq

28
UniProt

6
CCDS

CCDS19232.1, CCDS89913.1

Ensembl

ENSMUSG00000029098 (Evidence)
NCBI Gene

80911

			Length	Strain/Species	Flank
genomic	80911	NCBI Gene Model \| MGI Sequence Detail	32105	C57BL/6J	± kb
transcript	NM_001357018	RefSeq \| MGI Sequence Detail	4136	C57BL/6
polypeptide	Q9EPL9	UniProt \| EBI \| MGI Sequence Detail	700	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000003644 peroxisomal acyl-coenzyme A oxidase 3

(term hierarchy)
EC

1.3.3.6
InterPro Domains

IPR036250 Acyl-CoA dehydrogenase-like, C-terminal

IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily

IPR012258 Acyl-CoA oxidase

IPR002655 Acyl-CoA oxidase, C-terminal

IPR006091 Acyl-CoA oxidase/dehydrogenase, middle domain

IPR046373 Acyl-CoA oxidase/dehydrogenase, middle domain superfamily

IPR034171 Peroxisomal acyl-coenzyme A oxidase
GlyGen

Q9EPL9 1 site, 1 N-linked glycan (1 site)

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All nucleic 35

cDNA 33

Primer pair 1

Other 1

Microarray probesets 4

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MGI:2183033

Summaries

All 62

Developmental Gene Expression 5

Diseases 1

Gene Ontology 7

Phenotypes 30
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acox3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45950	Chr5:35740362-35740454 (+)	115 bp
Tssr45951	Chr5:35741033-35741055 (+)	751 bp
Tssr45952	Chr5:35745362-35745386 (+)	5,081 bp
Tssr45953	Chr5:35745387-35745388 (+)	5,095 bp
Tssr45954	Chr5:35745394-35745396 (+)	5,102 bp
Tssr45955	Chr5:35745401-35745412 (+)	5,114 bp
Tssr45956	Chr5:35749420-35749432 (+)	9,133 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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