Trim23 MGI Mouse Gene Detail - MGI:1933161 - tripartite motif-containing 23

Symbol

Trim23
Name

tripartite motif-containing 23
Synonyms

6330516O20Rik, Arfd1

Feature Type

protein coding gene
IDs

MGI:1933161
NCBI Gene: 81003
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr13:104315305-104339880 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 56.35 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

539 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933161	protein coding gene	Chr13:104315187-104339983 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020905	protein coding gene	Chr13:106269452-106293975 (+)
A/J	MGP_AJ_G0020856	protein coding gene	Chr13:102133951-102158517 (+)
AKR/J	MGP_AKRJ_G0020831	protein coding gene	Chr13:105244264-105268843 (+)
BALB/cJ	MGP_BALBcJ_G0020856	protein coding gene	Chr13:102842901-102867450 (+)
C3H/HeJ	MGP_C3HHeJ_G0020645	protein coding gene	Chr13:104980049-105004365 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021290	protein coding gene	Chr13:109464717-109489318 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018860	protein coding gene	Chr13:97751472-97777827 (+)
CAST/EiJ	MGP_CASTEiJ_G0020165	protein coding gene	Chr13:104445450-104473261 (+)
CBA/J	MGP_CBAJ_G0020607	protein coding gene	Chr13:113714111-113740704 (+)
DBA/2J	MGP_DBA2J_G0020731	protein coding gene	Chr13:101899492-101924100 (+)
FVB/NJ	MGP_FVBNJ_G0020713	protein coding gene	Chr13:100597444-100621867 (+)
LP/J	MGP_LPJ_G0020805	protein coding gene	Chr13:106294820-106319694 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020741	protein coding gene	Chr13:113879226-113927201 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021329	protein coding gene	Chr13:104718354-104742642 (+)
PWK/PhJ	MGP_PWKPhJ_G0019918	protein coding gene	Chr13:100634009-100658943 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019740	protein coding gene	Chr13:100914754-100942104 (+)
WSB/EiJ	MGP_WSBEiJ_G0020222	protein coding gene	Chr13:105185928-105211249 (+)

Human Ortholog

TRIM23, tripartite motif containing 23

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIM23, tripartite motif containing 23
Synonyms

ARD1, ARFD1, RNF46
Links

HGNC:660

NCBI Gene ID: 373

neXtProt AC: NX_P36406

UniProt: P36406
Chr Location

5q12.3; chr5:65589690-65625975 (-) GRCh38

MGI Vertebrate Homology

Trim23 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRIM23
Gene Tree

Trim23

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

4
Gene trapped

8
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit mild myopathy with sarcotubular myopathy, decreased fertility, and decreased axon diameter. Mice homozygous for a null allele display increased heart rate and increased chemical nociceptive threshold.

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All GO Annotations

33
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

15
cDNA Data

14
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trim23

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All Sequences

53
RefSeq

6
UniProt

2
CCDS

CCDS26747.1, CCDS88515.1, CCDS88516.1

Ensembl

ENSMUSG00000021712 (Evidence)
NCBI Gene

81003

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021712	Ensembl Gene Model \| MGI Sequence Detail	24576	C57BL/6J	± kb
transcript	ENSMUST00000022225	Ensembl \| MGI Sequence Detail	3416	Not Applicable
polypeptide	ENSMUSP00000022225	Ensembl \| MGI Sequence Detail	574	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016648 E3 ubiquitin-protein ligase TRIM23

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR003649 B-box, C-terminal

IPR000315 B-box-type zinc finger

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR006689 Small GTPase superfamily, ARF/SAR type

IPR024156 Small GTPase superfamily, ARF type

IPR005225 Small GTP-binding protein domain

IPR013087 Zinc finger C2H2-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

IPR027370 Zinc finger, RING-type, eukaryotic

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All nucleic 16

cDNA 16

Microarray probesets 7

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MGI:1923425, MGI:2145241

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:306292 Cao X, et al., Opposing roles of E3 ligases TRIM23 and TRIM21 in regulation of ion channel ANO1 protein levels. J Biol Chem. 2021 May 3;:100738

TSS for Trim23:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120910	Chr13:104315306-104315380 (+)	38 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24