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Tm6sf1 Gene Detail
Summary
  • Symbol
    Tm6sf1
  • Name
    transmembrane 6 superfamily member 1
  • Synonyms
    C630016D09Rik, MGC:25583
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933209
    NCBI Gene: 107769
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:81508749-81534182 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    791 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933209
 protein coding gene Chr7:81507810-81534182 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032439
 protein coding gene Chr7:83952883-83977882 (+)
A/J MGP_AJ_G0032417
 protein coding gene Chr7:81955204-81980176 (+)
AKR/J MGP_AKRJ_G0032353
 protein coding gene Chr7:83783044-83808048 (+)
BALB/cJ MGP_BALBcJ_G0032429
 protein coding gene Chr7:81620198-81646068 (+)
C3H/HeJ MGP_C3HHeJ_G0032143
 protein coding gene Chr7:84388972-84414795 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032920
 protein coding gene Chr7:87226432-87251864 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029930
 protein coding gene Chr7:84421253-84446639 (+)
CAST/EiJ MGP_CASTEiJ_G0031470
 protein coding gene Chr7:75329515-75355447 (+)
CBA/J MGP_CBAJ_G0032108
 protein coding gene Chr7:90143111-90169863 (+)
DBA/2J MGP_DBA2J_G0032263
 protein coding gene Chr7:80484614-80509618 (+)
FVB/NJ MGP_FVBNJ_G0032217
 protein coding gene Chr7:80421889-80446889 (+)
LP/J MGP_LPJ_G0032344
 protein coding gene Chr7:85175587-85201685 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032254
 protein coding gene Chr7:90198899-90223903 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032940
 protein coding gene Chr7:83193251-83218691 (+)
PWK/PhJ MGP_PWKPhJ_G0031190
 protein coding gene Chr7:73703540-73729632 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031032
 protein coding gene Chr7:70188755-70215084 (+)
WSB/EiJ MGP_WSBEiJ_G0031587
 protein coding gene Chr7:83556445-83582110 (+)



Homology
more
  • Human Ortholog
    TM6SF1, transmembrane 6 superfamily member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TM6SF1, transmembrane 6 superfamily member 1
  • Links
    NCBI Gene ID: 53346
    neXtProt AC: NX_Q9BZW5
    UniProt: Q9BZW5

  • Chr Location
    15q25.2; chr15:83107572-83144854 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    11
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038623 Ensembl Gene Model | MGI Sequence Detail 25434 C57BL/6J ±  kb
transcript ENSMUST00000041890 Ensembl | MGI Sequence Detail 2226 Not Applicable  
polypeptide ENSMUSP00000038017 Ensembl | MGI Sequence Detail 370 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141947, MGI:2384810, MGI:2441917
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 14
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:219217 Tam WY, et al., Transmembrane 6 superfamily 1 (Tm6sf1) is a novel lysosomal transmembrane protein. Protoplasma. 2015 Jul;252(4):977-83
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory