Sytl2 MGI Mouse Gene Detail - MGI:1933366

Symbol

Sytl2
Name

synaptotagmin-like 2
Synonyms

Slp2, Slp2-a, Slp2-b, Slp2-c, Slp2-d

Feature Type

protein coding gene
IDs

MGI:1933366
NCBI Gene: 83671
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:89951460-90059927 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 50.54 cM
Mapping Data

2 experiments

SNPs within 2kb

3544 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933366	protein coding gene	Chr7:89951421-90059927 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032505	protein coding gene	Chr7:92723134-92838676 (+)
A/J	MGP_AJ_G0032479	protein coding gene	Chr7:90539333-90600062 (+)
AKR/J	MGP_AKRJ_G0032415	protein coding gene	Chr7:92658392-92720264 (+)
BALB/cJ	MGP_BALBcJ_G0032490	protein coding gene	Chr7:90188331-90249801 (+)
C3H/HeJ	MGP_C3HHeJ_G0032205	protein coding gene	Chr7:92996370-93106291 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032988	protein coding gene	Chr7:96388406-96464800 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029983	protein coding gene	Chr7:93381311-93488354 (+)
CAST/EiJ	MGP_CASTEiJ_G0031532	protein coding gene	Chr7:84435711-84549361 (+)
CBA/J	MGP_CBAJ_G0032172	protein coding gene	Chr7:99611743-99674438 (+)
DBA/2J	MGP_DBA2J_G0032324	protein coding gene	Chr7:88971876-89033186 (+)
FVB/NJ	MGP_FVBNJ_G0032280	protein coding gene	Chr7:88836638-88898051 (+)
LP/J	MGP_LPJ_G0032413	protein coding gene	Chr7:94036838-94106499 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032314	protein coding gene	Chr7:100554260-100685644 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033010	protein coding gene	Chr7:91933759-91996551 (+)
PWK/PhJ	MGP_PWKPhJ_G0031250	protein coding gene	Chr7:81965302-82079720 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031093	protein coding gene	Chr7:79264622-79327643 (+)
WSB/EiJ	MGP_WSBEiJ_G0031649	protein coding gene	Chr7:92557687-92672251 (+)

Human Ortholog

SYTL2, synaptotagmin like 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SYTL2, synaptotagmin like 2
Synonyms

CHR11SYT, EXO4, PPP1R151, SGA72M, SLP2, SLP2A
Links

HGNC:15585

NCBI Gene ID: 54843

neXtProt AC: NX_Q9HCH5

UniProt: Q9HCH5
Chr Location

11q14.1; chr11:85694224-85854870 (-) GRCh38

MGI Vertebrate Homology

Sytl2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SYTL2
Gene Tree

Sytl2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

3
Targeted

4
Genomic Mutations

4 involving Sytl2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

62 strains or lines available

Mice homozygous for a null allele display abnormal gastric surface mucus cell morphology and reduced basal mucin secretion from gastric cells

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All GO Annotations

27
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

826
Tissues

12
cDNA Data

29
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sytl2

ZFIN sytl2a, sytl2b

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All Sequences

126
RefSeq

38
UniProt

11
CCDS

CCDS40017.1, CCDS40018.1, CCDS40019.1, CCDS80750.1, CCDS80751.1, CCDS90269.1

Ensembl

ENSMUSG00000030616 (Evidence)
NCBI Gene

83671

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030616	Ensembl Gene Model \| MGI Sequence Detail	108468	C57BL/6J	± kb
transcript	ENSMUST00000239078	Ensembl \| MGI Sequence Detail	7447	Not Applicable
polypeptide	ENSMUSP00000158976	Ensembl \| MGI Sequence Detail	2153	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000015913 synaptotagmin-like protein 2

(term hierarchy)
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR041282 FYVE-type zinc finger

IPR010911 Rab-binding domain

IPR043567 Synaptotagmin-like 1-5, C2B domain
GlyGen

Q99N50 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 37

cDNA 31

Primer pair 6

Microarray probesets 3

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MGI:2141893

Summaries

All 66

Developmental Gene Expression 4

Gene Ontology 12

Phenotypes 28
Earliest

J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
Latest

J:338901 Boogerd CJ, et al., Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation. Nat Commun. 2023 Aug 5;14(1):4716

TSS for Sytl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr67754	Chr7:89951445-89951456 (+)	-9 bp
Tssr67755	Chr7:89951567-89951605 (+)	126 bp
Tssr67756	Chr7:89951608-89951652 (+)	170 bp
Tssr67757	Chr7:90036183-90036226 (+)	84,745 bp
Tssr67758	Chr7:90036249-90036260 (+)	84,795 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24