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Bicc1 Gene Detail
Summary
  • Symbol
    Bicc1
  • Name
    BicC family RNA binding protein 1
  • Synonyms
    Bic-C, jcpk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933388
    NCBI Gene: 83675
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:70758662-70995530 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 36.75 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7519 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933388
 protein coding gene Chr10:70758660-70995581 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017341
 protein coding gene Chr10:70875106-71129523 (-)
A/J MGP_AJ_G0017318
 protein coding gene Chr10:68458799-68694813 (-)
AKR/J MGP_AKRJ_G0017279
 protein coding gene Chr10:70324714-70575060 (-)
BALB/cJ MGP_BALBcJ_G0017278
 protein coding gene Chr10:68660038-68895920 (-)
C3H/HeJ MGP_C3HHeJ_G0017102
 protein coding gene Chr10:70342816-70583591 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017736
 protein coding gene Chr10:73418126-73670191 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015426
 protein coding gene Chr10:65045645-65264708 (-)
CAST/EiJ MGP_CASTEiJ_G0016672
 protein coding gene Chr10:70496017-70731292 (-)
CBA/J MGP_CBAJ_G0017074
 protein coding gene Chr10:76249439-76523630 (-)
DBA/2J MGP_DBA2J_G0017179
 protein coding gene Chr10:67815410-68047199 (-)
FVB/NJ MGP_FVBNJ_G0017172
 protein coding gene Chr10:66988208-67220725 (-)
LP/J MGP_LPJ_G0017252
 protein coding gene Chr10:71317863-71579038 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017200
 protein coding gene Chr10:78335695-78595203 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017775
 protein coding gene Chr10:70288075-70535824 (-)
PWK/PhJ MGP_PWKPhJ_G0016456
 protein coding gene Chr10:67664104-67898295 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016239
 protein coding gene Chr10:69664332-69896935 (-)
WSB/EiJ MGP_WSBEiJ_G0016736
 protein coding gene Chr10:70236369-70478675 (-)



Homology
more
  • Human Ortholog
    BICC1, BicC family RNA binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BICC1, BicC family RNA binding protein 1
  • Synonyms
    BICC, CYSRD
  • Links
    NCBI Gene ID: 80114
    neXtProt AC: NX_Q9H694
    UniProt: Q9H694

  • Chr Location
    10q21.1; chr10:58512220-58831435 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with Bicc1 mouse models; 1 with human BICC1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 6 models
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotypes from 8 alleles in 12 genetic backgrounds
    15 phenotypes from multigenic genotypes
    15 images
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes heteroxia, impaired nodal flow, ventricular septal defects, partial prenatal lethality and postnatal death due to renal failure. Chemically induced mutants develop kidney cysts and may show bulging abdomens, bile duct anomalies and cardiovascular defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    919
  • Tissues
    124
  • cDNA Data
    14
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014329 Ensembl Gene Model | MGI Sequence Detail 236869 C57BL/6J ±  kb
    transcript ENSMUST00000143791 Ensembl | MGI Sequence Detail 5431 Not Applicable  
    polypeptide ENSMUSP00000123201 Ensembl | MGI Sequence Detail 977 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 15
      Primer pair 5
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11521, MGD-MRK-18744, MGI:101915, MGI:96633
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 18
      Diseases 6
      Gene Ontology 9
      Phenotypes 43
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory