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Akr1c6 Gene Detail
Summary
  • Symbol
    Akr1c6
  • Name
    aldo-keto reductase family 1, member C6
  • Synonyms
    3alpha-HSD, Akr1c1, estradiol 17-beta-dehydrogenase (A-specific), Hsd17b5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933427
    NCBI Gene: 83702
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:4484354-4507529 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 2.48 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    717 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933427
 protein coding gene Chr13:4484305-4507876 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020207
 protein coding gene Chr13:918216-942011 (+)
A/J MGP_AJ_G0020163
 protein coding gene Chr13:1016579-1037334 (+)
AKR/J MGP_AKRJ_G0020138
 protein coding gene Chr13:1053261-1076008 (+)
BALB/cJ MGP_BALBcJ_G0020146
 protein coding gene Chr13:1019651-1042942 (+)
C3H/HeJ MGP_C3HHeJ_G0019950
 protein coding gene Chr13:1124050-1149354 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020593
 protein coding gene Chr13:1035191-1057284 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018204
 protein coding gene Chr13:1077491-1095284 (+)
CAST/EiJ MGP_CASTEiJ_G0019490
 protein coding gene Chr13:933408-934022 (+)
CBA/J MGP_CBAJ_G0019917
 protein coding gene Chr13:1014173-1044024 (+)
DBA/2J MGP_DBA2J_G0020034
 protein coding gene Chr13:932563-955926 (+)
FVB/NJ MGP_FVBNJ_G0020019
 protein coding gene Chr13:897206-921293 (+)
LP/J MGP_LPJ_G0020108
 protein coding gene Chr13:1009587-1032811 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020055
 protein coding gene Chr13:1119841-1146522 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020621
 protein coding gene Chr13:989068-1011853 (+)
PWK/PhJ MGP_PWKPhJ_G0019251
 protein coding gene Chr13:996225-996839 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019058
 protein coding gene Chr13:1050480-1077650 (+)
WSB/EiJ MGP_WSBEiJ_G0019548
 protein coding gene Chr13:943899-964583 (+)



Homology
more
  • Human Ortholog
    AKR1C1, aldo-keto reductase family 1 member C1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKR1C1, aldo-keto reductase family 1 member C1
  • Synonyms
    20-ALPHA-HSD, 2-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB
  • Links
    NCBI Gene ID: 1645
    neXtProt AC: NX_Q04828
    UniProt: Q04828

  • Chr Location
    10p15.1; chr10:4963253-4983283 (+)  GRCh38
  • Human Ortholog
    AKR1C2, aldo-keto reductase family 1 member C2
  • Synonyms
    AKR1C-pseudo, BABP, DD, DD-2, DD2, DD/BABP, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
  • Links
    NCBI Gene ID: 1646
    neXtProt AC: NX_P52895
    UniProt: P52895

  • Chr Location
    10p15.1; chr10:4987775-5018031 (-)  GRCh38
  • Human Ortholog
    AKR1C3, aldo-keto reductase family 1 member C3
  • Synonyms
    DD3, DDX, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, PGFS
  • Links
    NCBI Gene ID: 8644
    neXtProt AC: NX_P42330
    UniProt: P42330

  • Chr Location
    10p15.1; chr10:5035354-5107686 (+)  GRCh38
  • Human Ortholog
    AKR1C4, aldo-keto reductase family 1 member C4
  • Synonyms
    3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA
  • Links
    NCBI Gene ID: 1109
    neXtProt AC: NX_P17516
    UniProt: P17516

  • Chr Location
    10p15.1; chr10:5195462-5218949 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human AKR1C2,AKR1C3,AKR1C4 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1027
  • Tissues
    231
  • cDNA Data
    116
  • Literature Summary
    12
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 83702 NCBI Gene Model | MGI Sequence Detail 23176 C57BL/6J ±  kb
transcript NM_030611 RefSeq | MGI Sequence Detail 1347 ZRU/MplStud  
polypeptide P70694 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 118
    Genomic 1
    cDNA 116
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1096387, MGI:1931562
References
more
  • Summaries
    All 44
    Developmental Gene Expression 12
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:25103 Deyashiki Y, et al., Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family. J Biol Chem. 1995 May 5;270(18):10461-7
  • Latest
    J:313927 Gannon AL, et al., Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity. Front Endocrinol (Lausanne). 2020;11:599869
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory