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Actl6b Gene Detail
Summary
  • Symbol
    Actl6b
  • Name
    actin-like 6B
  • Synonyms
    Actl6, ArpNa, Baf53b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933548
    NCBI Gene: 83766
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137551784-137567844 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.56 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    418 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933548
 protein coding gene Chr5:137551779-137567844 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030231
 protein coding gene Chr5:142323352-142340133 (+)
A/J MGP_AJ_G0030199
 protein coding gene Chr5:136114446-136130742 (+)
AKR/J MGP_AKRJ_G0030132
 protein coding gene Chr5:140538138-140554899 (+)
BALB/cJ MGP_BALBcJ_G0030209
 protein coding gene Chr5:137484112-137501990 (+)
C3H/HeJ MGP_C3HHeJ_G0029925
 protein coding gene Chr5:141186464-141203819 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030661
 protein coding gene Chr5:147579025-147594589 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027879
 protein coding gene Chr5:130362613-130378485 (+)
CAST/EiJ MGP_CASTEiJ_G0029335
 protein coding gene Chr5:140593205-140611239 (+)
CBA/J MGP_CBAJ_G0029895
 protein coding gene Chr5:153447871-153466377 (+)
DBA/2J MGP_DBA2J_G0030046
 protein coding gene Chr5:136018304-136034465 (+)
FVB/NJ MGP_FVBNJ_G0030001
 protein coding gene Chr5:135227054-135243258 (+)
LP/J MGP_LPJ_G0030135
 protein coding gene Chr5:142780264-142811199 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030033
 protein coding gene Chr5:156273290-156289792 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030702
 protein coding gene Chr5:140389049-140408009 (+)
PWK/PhJ MGP_PWKPhJ_G0029048
 protein coding gene Chr5:135106726-135124586 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028884
 protein coding gene Chr5:137953144-137968646 (+)
WSB/EiJ MGP_WSBEiJ_G0029408
 protein coding gene Chr5:141120442-141140405 (+)



Homology
more
  • Human Ortholog
    ACTL6B, actin like 6B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACTL6B, actin like 6B
  • Synonyms
    ACTL6, arpNalpha, BAF53B, DEE76, EIEE76, IDDSSAD, SMARCN2
  • Links
    NCBI Gene ID: 51412
    neXtProt AC: NX_O94805
    UniProt: O94805

  • Chr Location
    7q22.1; chr7:100643097-100656448 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ACTL6B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null mutations exhibit low survivor rate and most die within 2 days after birth and show hyperactivity due to reduced dendrite formation in neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    826
  • Tissues
    28
  • cDNA Data
    17
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83766 NCBI Gene Model | MGI Sequence Detail 16061 C57BL/6J ±  kb
    transcript NM_001425790 RefSeq | MGI Sequence Detail 1586 C57BL/6  
    polypeptide Q99MR0 UniProt | EBI | MGI Sequence Detail 426 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 17
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 15
      Gene Ontology 27
      Phenotypes 13
    • Earliest
      J:35263 Wang W, et al., Diversity and specialization of mammalian SWI/SNF complexes. Genes Dev. 1996 Sep 1;10(17):2117-30
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory