Dnaja3 MGI Mouse Gene Detail - MGI:1933786 - DnaJ heat shock protein family (Hsp40) member A3

Symbol

Dnaja3
Name

DnaJ heat shock protein family (Hsp40) member A3
Synonyms

1200003J13Rik, 1810053A11Rik, Tid-1

Feature Type

protein coding gene
IDs

MGI:1933786
NCBI Gene: 83945
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr16:4501934-4525559 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 2.46 cM
Mapping Data

3 experiments

SNPs within 2kb

525 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933786	protein coding gene	Chr16:4457853-4525559 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022469	protein coding gene	Chr16:1142661-1217898 (+)
A/J	MGP_AJ_G0022431	protein coding gene	Chr16:966661-1034017 (+)
AKR/J	MGP_AKRJ_G0022408	protein coding gene	Chr16:1155338-1226091 (+)
BALB/cJ	MGP_BALBcJ_G0022436	protein coding gene	Chr16:1120258-1190884 (+)
C3H/HeJ	MGP_C3HHeJ_G0022203	protein coding gene	Chr16:1171950-1247348 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022885	protein coding gene	Chr16:1221757-1302580 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020406	protein coding gene	Chr16:908433-977041 (+)
CAST/EiJ	MGP_CASTEiJ_G0021729	protein coding gene	Chr16:1161236-1239505 (+)
CBA/J	MGP_CBAJ_G0022172	protein coding gene	Chr16:1282456-1358088 (+)
DBA/2J	MGP_DBA2J_G0022303	protein coding gene	Chr16:1078162-1147226 (+)
FVB/NJ	MGP_FVBNJ_G0022278	protein coding gene	Chr16:1062847-1131644 (+)
LP/J	MGP_LPJ_G0022371	protein coding gene	Chr16:1144942-1215245 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022300	protein coding gene	Chr16:1154851-1228146 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022897	protein coding gene	Chr16:1119306-1189607 (+)
PWK/PhJ	MGP_PWKPhJ_G0021469	protein coding gene	Chr16:1138388-1209188 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021300	protein coding gene	Chr16:1208439-1287567 (+)
WSB/EiJ	MGP_WSBEiJ_G0021778	protein coding gene	Chr16:1132293-1211458 (+)

Human Ortholog

DNAJA3, DnaJ heat shock protein family (Hsp40) member A3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJA3, DnaJ heat shock protein family (Hsp40) member A3
Synonyms

HCA57, hTID-1, TID1, Tid1-L, Tid1-S
Links

HGNC:11808

NCBI Gene ID: 9093

neXtProt AC: NX_Q96EY1

UniProt: Q96EY1
Chr Location

16p13.3; chr16:4425805-4456775 (+) GRCh38

MGI Vertebrate Homology

Dnaja3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DNAJA3
Gene Tree

Dnaja3

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Phenotype Summary

21 phenotypes from 3 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

2
Targeted

8
Incidental Mutations

APF
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Early embryonic development of homozygous null embryos is disrupted. Blastocysts develop and implant but die afterwards.

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All GO Annotations

73
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnaja3

ZFIN dnaja3a, dnaja3b

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All Sequences

61
RefSeq

4
UniProt

2
CCDS

CCDS27922.1, CCDS49748.1

Ensembl

ENSMUSG00000004069 (Evidence)
NCBI Gene

83945

			Length	Strain/Species	Flank
genomic	83945	NCBI Gene Model \| MGI Sequence Detail	23626	C57BL/6J	± kb
transcript	NM_023646	RefSeq \| MGI Sequence Detail	2666	ZRU/MplStud
polypeptide	Q99M87	UniProt \| EBI \| MGI Sequence Detail	480	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006572 DnaJ homolog subfamily A member 3, mitochondrial

(term hierarchy)
InterPro Domains

IPR051938 Apoptosis and cytoskeleton modulation protein

IPR012724 Chaperone DnaJ

IPR002939 Chaperone DnaJ, C-terminal

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR018253 DnaJ domain, conserved site

IPR001305 Heat shock protein DnaJ, cysteine-rich domain

IPR036410 Heat shock protein DnaJ, cysteine-rich domain superfamily

IPR008971 HSP40/DnaJ peptide-binding
GlyGen

Q99M87 1 site, 1 O-linked glycan (1 site)

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All nucleic 16

cDNA 16

Microarray probesets 5

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MGI:1914108, MGI:1919302, MGI:2146711

Summaries

All 49

Developmental Gene Expression 2

Gene Ontology 14

Phenotypes 12
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:331835 Salazar-Petres E, et al., Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice. Biol Reprod. 2022 Jun 13;106(6):1292-1311

TSS for Dnaja3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136865	Chr16:4501963-4502001 (+)	48 bp
Tssr136866	Chr16:4502093-4502100 (+)	163 bp
Tssr136867	Chr16:4519046-4519059 (+)	17,119 bp
Tssr136868	Chr16:4524989-4524994 (+)	23,058 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24