Jam2 MGI Mouse Gene Detail - MGI:1933820 - junction adhesion molecule 2

Symbol

Jam2
Name

junction adhesion molecule 2
Synonyms

2410030G21Rik, 2410167M24Rik, JAM-2, Jcam2, VE-JAM

Feature Type

protein coding gene
IDs

MGI:1933820
NCBI Gene: 67374
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr16:84571011-84622816 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 46.92 cM
Mapping Data

2 experiments

SNPs within 2kb

1735 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933820	protein coding gene	Chr16:84571011-84623268 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022968	protein coding gene	Chr16:85347727-85408105 (+)
A/J	MGP_AJ_G0022936	protein coding gene	Chr16:81460379-81515716 (+)
AKR/J	MGP_AKRJ_G0022906	protein coding gene	Chr16:83862294-83915770 (+)
BALB/cJ	MGP_BALBcJ_G0022938	protein coding gene	Chr16:81918700-81974226 (+)
C3H/HeJ	MGP_C3HHeJ_G0022700	protein coding gene	Chr16:84434672-84490880 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023385	protein coding gene	Chr16:88125093-88181932 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020889	protein coding gene	Chr16:79406002-79461924 (+)
CAST/EiJ	MGP_CASTEiJ_G0022222	protein coding gene	Chr16:84878016-84936655 (+)
CBA/J	MGP_CBAJ_G0022669	protein coding gene	Chr16:91885045-91940473 (+)
DBA/2J	MGP_DBA2J_G0022803	protein coding gene	Chr16:81343110-81395008 (+)
FVB/NJ	MGP_FVBNJ_G0022778	protein coding gene	Chr16:80541668-80594137 (+)
LP/J	MGP_LPJ_G0022872	protein coding gene	Chr16:85035798-85093521 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022797	protein coding gene	Chr16:96327420-96400165 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023403	protein coding gene	Chr16:84340021-84395045 (+)
PWK/PhJ	MGP_PWKPhJ_G0021964	protein coding gene	Chr16:81501580-81556577 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021794	protein coding gene	Chr16:83831957-83887730 (+)
WSB/EiJ	MGP_WSBEiJ_G0022270	protein coding gene	Chr16:84589219-84643346 (+)

Human Ortholog

JAM2, junctional adhesion molecule 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

JAM2, junctional adhesion molecule 2
Synonyms

C21orf43, CD322, IBGC8, JAM-B, JAMB, PRO245, VE-JAM, VEJAM
Links

HGNC:14686

NCBI Gene ID: 58494

neXtProt AC: NX_P57087

UniProt: P57087
Chr Location

21q21.3; chr21:25639258-25717562 (+) GRCh38

MGI Vertebrate Homology

Jam2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: JAM2
Gene Tree

Jam2

Diseases

1 with human JAM2 associations

				Human Disease	Mouse Models
				basal ganglia calcification IDs basal ganglia calcification DOID:0060230 MESH:C536275 OMIM:114100 OMIM:213600 OMIM:615007 OMIM:615483 UMLS_CUI:C0393590

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

13 phenotypes from 4 alleles in 4 genetic backgrounds
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

299
Endonuclease-mediated

1
Gene trapped

288
Targeted

9
Genomic Mutations

4 involving Jam2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

121 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele are viable, fertile and overtly normal with no detectable spermatogenesis abnormalities or defects in embryonic, neural and hematopoietic stem cell properties.

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All GO Annotations

35
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

999
Tissues

168
cDNA Data

46
Literature Summary

21

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA JAM2

Xenbase jam2

ZFIN jam2a, jam2b

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All Sequences

51
RefSeq

4
UniProt

3
CCDS

CCDS37381.1

Ensembl

ENSMUSG00000053062 (Evidence)
NCBI Gene

67374

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053062	Ensembl Gene Model \| MGI Sequence Detail	51806	C57BL/6J	± kb
transcript	ENSMUST00000231910	Ensembl \| MGI Sequence Detail	1214	Not Applicable
polypeptide	ENSMUSP00000156235	Ensembl \| MGI Sequence Detail	322	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001872 junctional adhesion molecule B

(term hierarchy)
PDB

5GMJ
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain

IPR042625 Junctional adhesion molecule B
GlyGen

Q9JI59 3 sites, 4 N-linked glycans (3 sites)

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All nucleic 54

cDNA 47

Primer pair 5

Other 2

Microarray probesets 9

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MGI:1914168, MGI:1924075, MGI:2146545

Summaries

All 92

Developmental Gene Expression 21

Diseases 1

Gene Ontology 10

Phenotypes 35
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Jam2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139177	Chr16:84569891-84569896 (+)	-1,117 bp
Tssr139178	Chr16:84570540-84570543 (+)	-469 bp
Tssr139179	Chr16:84570743-84570763 (+)	-258 bp
Tssr139180	Chr16:84570778-84570792 (+)	-226 bp
Tssr139181	Chr16:84570974-84570981 (+)	-33 bp
Tssr139182	Chr16:84571024-84571033 (+)	18 bp
Tssr139183	Chr16:84571051-84571062 (+)	46 bp
Tssr139184	Chr16:84571063-84571085 (+)	63 bp
Tssr139185	Chr16:84571117-84571126 (+)	111 bp
Tssr139186	Chr16:84571151-84571182 (+)	156 bp
Tssr139187	Chr16:84571189-84571202 (+)	185 bp
Tssr139188	Chr16:84571209-84571220 (+)	204 bp
Tssr139189	Chr16:84571249-84571311 (+)	269 bp
Tssr139190	Chr16:84571316-84571327 (+)	311 bp
Tssr139191	Chr16:84580606-84580611 (+)	9,598 bp
Tssr139192	Chr16:84590434-84590444 (+)	19,428 bp
Tssr139193	Chr16:84590448-84590462 (+)	19,444 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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