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Nrg4 Gene Detail
Summary
  • Symbol
    Nrg4
  • Name
    neuregulin 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933833
    NCBI Gene: 83961
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:55127506-55190937 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 29.87 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1800 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933833
 protein coding gene Chr9:55127506-55234128 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034840
 protein coding gene Chr9:54304722-54420155 (-)
A/J MGP_AJ_G0034821
 protein coding gene Chr9:52559112-52667479 (-)
AKR/J MGP_AKRJ_G0034750
 protein coding gene Chr9:53762736-53873292 (-)
BALB/cJ MGP_BALBcJ_G0034813
 protein coding gene Chr9:52333021-52440579 (-)
C3H/HeJ MGP_C3HHeJ_G0034523
 protein coding gene Chr9:54224008-54332843 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035332
 protein coding gene Chr9:55817375-55930969 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032244
 protein coding gene Chr9:51965783-52069988 (-)
CAST/EiJ MGP_CASTEiJ_G0033844
 protein coding gene Chr9:54261323-54369327 (-)
CBA/J MGP_CBAJ_G0034494
 protein coding gene Chr9:57766557-57881089 (-)
DBA/2J MGP_DBA2J_G0034653
 protein coding gene Chr9:52451840-52558878 (-)
FVB/NJ MGP_FVBNJ_G0034595
 protein coding gene Chr9:51652993-51760554 (-)
LP/J MGP_LPJ_G0034736
 protein coding gene Chr9:54615275-54725505 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034638
 protein coding gene Chr9:59277450-59394429 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035354
 protein coding gene Chr9:53779428-53890836 (-)
PWK/PhJ MGP_PWKPhJ_G0033549
 protein coding gene Chr9:52436877-52544709 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033384
 protein coding gene Chr9:54038039-54154756 (-)
WSB/EiJ MGP_WSBEiJ_G0033957
 protein coding gene Chr9:53733912-53846077 (-)



Homology
more
  • Human Ortholog
    NRG4, neuregulin 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRG4, neuregulin 4
  • Synonyms
    HRG4
  • Links
    NCBI Gene ID: 145957
    neXtProt AC: NX_Q8WWG1
    UniProt: Q8WWG1

  • Chr Location
    15q24.2; chr15:75935393-76060240 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    22 phenotype references
A gene trap insertion into an intron of this gene results in no obvious phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    34
  • cDNA Data
    10
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 83961 NCBI Gene Model | MGI Sequence Detail 63432 C57BL/6J ±  kb
transcript NR_189137 RefSeq | MGI Sequence Detail 2031 C57BL/6  
polypeptide Q9WTX4 UniProt | EBI | MGI Sequence Detail 115 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 13
    Primer pair 4
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2143092
References
more
  • Summaries
    All 56
    Developmental Gene Expression 9
    Gene Ontology 4
    Phenotypes 22
  • Earliest
    J:66947 Harari D, et al., Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. Oncogene. 1999 Apr 29;18(17):2681-9
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory