Tra2a MGI Mouse Gene Detail - MGI:1933972

Symbol

Tra2a
Name

transformer 2 alpha
Synonyms

1500010G04Rik, G430041M01Rik, mAWMS1

Feature Type

protein coding gene
IDs

MGI:1933972
NCBI Gene: 101214
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:49220858-49240967 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 23.84 cM
Mapping Data

2 experiments

SNPs within 2kb

436 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933972	protein coding gene	Chr6:49220855-49241182 (-)
129S1/SvImJ	ENSMUSG00200005063	protein coding gene	Chr6:46126817-46146924 (-)
A/J	ENSMUSG00195006796	protein coding gene	Chr6:45896821-45917180 (-)
AKR/J	ENSMUSG00220002959	protein coding gene	Chr6:45606461-45626495 (-)
BALB/cJ	ENSMUSG00180020037	protein coding gene	Chr6:46209899-46229938 (-)
C3H/HeJ	ENSMUSG00175016915	protein coding gene	Chr6:45971472-45991509 (-)
C57BL/6NJ	ENSMUSG00215006696	protein coding gene	Chr6:46171869-46191975 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028365	protein coding gene	Chr6:43643041-43662896 (-)
CAST/EiJ	ENSTCUG00005004233	protein coding gene	Chr6:45477805-45497881 (-)
CBA/J	ENSMUSG00210017845	protein coding gene	Chr6:46016337-46036375 (-)
DBA/2J	ENSMUSG00185013615	protein coding gene	Chr6:46598023-46618060 (-)
FVB/NJ	ENSMUSG00205024628	protein coding gene	Chr6:46262520-46282555 (-)
JF1/MsJ	ENSUMUG00000012419	protein coding gene	Chr6:45972121-45992672 (-)
LP/J	ENSMUSG00230017316	protein coding gene	Chr6:47623859-47643965 (-)
NOD/ShiLtJ	ENSMUSG00190025222	protein coding gene	Chr6:45936027-45956383 (-)
NZO/HlLtJ	ENSMUSG00225015797	protein coding gene	Chr6:49660447-49680553 (-)
PWK/PhJ	ENSLUMG00010018645	protein coding gene	Chr6:45595862-45616249 (-)
SPRET/EiJ	ENSMSPG00010008363	protein coding gene	Chr6:46213059-46232989 (-)
WSB/EiJ	ENSIUOG00005025458	protein coding gene	Chr6:46232654-46252761 (-)

Human Ortholog

TRA2A, transformer 2 alpha homolog

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRA2A, transformer 2 alpha homolog
Synonyms

AWMS1, HSU53209
Links

HGNC:16645

NCBI Gene ID: 29896

UniProt: Q13595
Chr Location

7p15.3; chr7:23504780-23532041 (-) GRCh38

MGI Vertebrate Homology

Tra2a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRA2A
Gene Tree

Tra2a

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Endonuclease-mediated

4
Gene trapped

25
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available

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All GO Annotations

19
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

649
Tissues

38
cDNA Data

16
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tra2a

ZFIN tra2a

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All Sequences

159
RefSeq

98
UniProt

9
CCDS

CCDS39486.1, CCDS85044.1

Ensembl

ENSMUSG00000029817 (Evidence)
NCBI Gene

101214

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029817	Ensembl Gene Model \| MGI Sequence Detail	20110	C57BL/6J	± kb
transcript	ENSMUST00000031841	Ensembl \| MGI Sequence Detail	1799	Not Applicable
polypeptide	ENSMUSP00000031841	Ensembl \| MGI Sequence Detail	282	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000016599 transformer-2 protein homolog alpha

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR050441 RNA-binding motif

IPR000504 RNA recognition motif domain
GlyGen

Q6PFR5 2 sites

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All nucleic 23

Genomic 1

cDNA 19

Primer pair 3

Microarray probesets 9

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MGI:1916215, MGI:2141532

Summaries

All 50

Developmental Gene Expression 7

Gene Ontology 9

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:360526 Shen CL, et al., RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar foliation. Commun Biol. 2024 Dec 30;7(1):1712

TSS for Tra2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr60888	Chr6:49240948-49240994 (-)	-4 bp
Tssr60887	Chr6:49240913-49240924 (-)	48 bp
Tssr60886	Chr6:49231207-49231222 (-)	9,752 bp
Tssr60885	Chr6:49230006-49230019 (-)	10,954 bp
Tssr60884	Chr6:49222474-49222508 (-)	18,476 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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