Gpr84 MGI Mouse Gene Detail - MGI:1934129 - G protein-coupled receptor 84

Symbol

Gpr84
Name

G protein-coupled receptor 84
Synonyms

EX33

Feature Type

protein coding gene
IDs

MGI:1934129
NCBI Gene: 80910
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:103216662-103219039 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 58.88 cM
Mapping Data

1 experiment

SNPs within 2kb

95 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1934129	protein coding gene	Chr15:103216660-103219050 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022438	protein coding gene	Chr15:105574940-105579013 (-)
A/J	MGP_AJ_G0022400	protein coding gene	Chr15:101392180-101394373 (-)
AKR/J	MGP_AKRJ_G0022375	protein coding gene	Chr15:104472565-104474761 (-)
BALB/cJ	MGP_BALBcJ_G0022404	protein coding gene	Chr15:101437206-101439406 (-)
C3H/HeJ	MGP_C3HHeJ_G0022171	protein coding gene	Chr15:104564777-104566968 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022853	protein coding gene	Chr15:109457959-109460161 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020376	protein coding gene	Chr15:97154639-97156821 (-)
CAST/EiJ	MGP_CASTEiJ_G0021697	protein coding gene	Chr15:105436174-105438378 (-)
CBA/J	MGP_CBAJ_G0022140	protein coding gene	Chr15:113307562-113309755 (-)
DBA/2J	MGP_DBA2J_G0022271	protein coding gene	Chr15:100668206-100670397 (-)
FVB/NJ	MGP_FVBNJ_G0022247	protein coding gene	Chr15:99727884-99730075 (-)
LP/J	MGP_LPJ_G0022340	protein coding gene	Chr15:105708808-105711010 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022269	protein coding gene	Chr15:116809558-116811749 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022865	protein coding gene	Chr15:104507698-104509891 (-)
PWK/PhJ	MGP_PWKPhJ_G0021437	protein coding gene	Chr15:100848292-100850487 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021269	protein coding gene	Chr15:104343879-104346079 (-)
WSB/EiJ	MGP_WSBEiJ_G0021747	protein coding gene	Chr15:105129977-105132170 (-)

Human Ortholog

GPR84, G protein-coupled receptor 84

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR84, G protein-coupled receptor 84
Synonyms

EX33, GPCR4
Links

HGNC:4535

NCBI Gene ID: 53831

neXtProt AC: NX_Q9NQS5

UniProt: Q9NQS5
Chr Location

12q13.13; chr12:54350698-54364487 (-) GRCh38

MGI Vertebrate Homology

Gpr84 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPR84
Gene Tree

Gpr84

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

6
Spontaneous

1
Targeted

5
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced IL4 production in response to CD3 crosslinking.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

11
cDNA Data

4
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpr84

ZFIN gpr84

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All Sequences

33
RefSeq

6
UniProt

2
CCDS

CCDS27902.1

Ensembl

ENSMUSG00000063234 (Evidence)
NCBI Gene

80910

			Length	Strain/Species	Flank
genomic	ENSMUSG00000063234	Ensembl Gene Model \| MGI Sequence Detail	2378	C57BL/6J	± kb
transcript	ENSMUST00000079824	Ensembl \| MGI Sequence Detail	1725	Not Applicable
polypeptide	ENSMUSP00000078753	Ensembl \| MGI Sequence Detail	396	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001540 G-protein coupled receptor 84

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q8CIM5 2 sites

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All nucleic 5

Genomic 1

cDNA 4

Microarray probesets 2

Summaries

All 51

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 24
Earliest

J:68335 Wittenberger T, et al., An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. J Mol Biol. 2001 Mar 30;307(3):799-813
Latest

J:357565 Cooper PO, et al., G-protein-coupled receptor 84 regulates acute inflammation in normal and diabetic skin wounds. Cell Rep. 2024 Jun 25;43(6):114288

TSS for Gpr84:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136752	Chr15:103218875-103218903 (-)	150 bp
Tssr136751	Chr15:103218852-103218871 (-)	177 bp
Tssr136750	Chr15:103218829-103218840 (-)	204 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24