Cd96 MGI Mouse Gene Detail - MGI:1934368

Symbol

Cd96
Name

CD96 antigen
Synonyms

1700109I12Rik, Tactile

Feature Type

protein coding gene
IDs

MGI:1934368
NCBI Gene: 84544
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr16:45856020-45940614 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 30.45 cM, cytoband B5
Mapping Data

2 experiments

SNPs within 2kb

2821 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1934368	protein coding gene	Chr16:45856015-45940614 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022861	protein coding gene	Chr16:44848086-44931705 (-)
A/J	MGP_AJ_G0022826	protein coding gene	Chr16:42845178-42929924 (-)
AKR/J	MGP_AKRJ_G0022798	protein coding gene	Chr16:44241739-44320565 (-)
BALB/cJ	MGP_BALBcJ_G0022827	protein coding gene	Chr16:42863278-42945862 (-)
C3H/HeJ	MGP_C3HHeJ_G0022591	protein coding gene	Chr16:44401102-44481057 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023274	protein coding gene	Chr16:45864899-45949040 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020788	protein coding gene	Chr16:43197710-43282458 (-)
CAST/EiJ	MGP_CASTEiJ_G0022116	protein coding gene	Chr16:44605487-44684644 (-)
CBA/J	MGP_CBAJ_G0022562	protein coding gene	Chr16:47781280-47868090 (-)
DBA/2J	MGP_DBA2J_G0022694	protein coding gene	Chr16:42574638-42657908 (-)
FVB/NJ	MGP_FVBNJ_G0022670	protein coding gene	Chr16:42488555-42574827 (-)
LP/J	MGP_LPJ_G0022762	protein coding gene	Chr16:44599031-44688386 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022688	protein coding gene	Chr16:47187824-47276072 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023289	protein coding gene	Chr16:44258690-44342434 (-)
PWK/PhJ	MGP_PWKPhJ_G0021856	protein coding gene	Chr16:42949488-43028269 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021687	protein coding gene	Chr16:44185926-44269398 (-)
WSB/EiJ	MGP_WSBEiJ_G0022161	protein coding gene	Chr16:44355544-44436994 (-)

Human Ortholog

CD96, CD96 molecule

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD96, CD96 molecule
Synonyms

TACTILE
Links

HGNC:16892

NCBI Gene ID: 10225

neXtProt AC: NX_P40200

UniProt: P40200
Chr Location

3q13.13-q13.2; chr3:111292719-111665996 (+) GRCh38

MGI Vertebrate Homology

Cd96 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CD96
Gene Tree

Cd96

Diseases

1 with human CD96 associations

				Human Disease	Mouse Models
				C syndrome IDs C syndrome DOID:0111581 MESH:C537418 OMIM:211750 ORDO:1308 UMLS_CUI:C0796095

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

7
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available

Mice homozygous for a knock-out allele exhibit hyperinflammatory responses after LPS challenge and increased susceptibility to endotoxin shock but are more resistant to MCA-induced generation of fibrosarcomas or to experimental lung metastases.

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

786
Tissues

19
cDNA Data

22
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

4
UniProt

2
CCDS

CCDS37348.1

Ensembl

ENSMUSG00000022657 (Evidence)
NCBI Gene

84544

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022657	Ensembl Gene Model \| MGI Sequence Detail	84595	C57BL/6J	± kb
transcript	ENSMUST00000023336	Ensembl \| MGI Sequence Detail	2184	Not Applicable
polypeptide	ENSMUSP00000023336	Ensembl \| MGI Sequence Detail	602	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001840 T-cell surface protein tactile

(term hierarchy)
PDB

7S11, 7S13
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR042381 T-cell surface protein tactile
GlyGen

Q3U0X8 16 sites

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All nucleic 23

cDNA 22

Other 1

Microarray probesets 3

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MGI:1920816

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cd96:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr141289	Chr16:45940789-45940800 (-)	-181 bp
Tssr4888	Chr16:45940621-45940624 (-)	-9 bp
Tssr141288	Chr16:45940601-45940617 (-)	5 bp
Tssr141287	Chr16:45940554-45940574 (-)	50 bp
Tssr141286	Chr16:45940548-45940553 (-)	63 bp
Tssr141285	Chr16:45940501-45940544 (-)	91 bp
Tssr141284	Chr16:45940482-45940500 (-)	123 bp
Tssr141283	Chr16:45869602-45869626 (-)	71,000 bp
Tssr141282	Chr16:45859731-45859748 (-)	80,874 bp
Tssr141281	Chr16:45858965-45858986 (-)	81,638 bp
Tssr141280	Chr16:45858939-45858944 (-)	81,672 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24