Tex15 MGI Mouse Gene Detail - MGI:1934816 - testis expressed gene 15 meiosis and synapsis associated

Symbol

Tex15
Name

testis expressed gene 15 meiosis and synapsis associated
Synonyms

2210014E14Rik

Feature Type

protein coding gene
IDs

MGI:1934816
NCBI Gene: 104271
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:34006766-34075610 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 20.59 cM
Mapping Data

3 experiments

SNPs within 2kb

1222 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1934816	protein coding gene	Chr8:34006712-34082531 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033523	protein coding gene	Chr8:31968239-32039523 (+)
A/J	MGP_AJ_G0033503	protein coding gene	Chr8:30741948-30810175 (+)
AKR/J	MGP_AKRJ_G0033427	protein coding gene	Chr8:31699846-31771097 (+)
BALB/cJ	MGP_BALBcJ_G0033499	protein coding gene	Chr8:30863805-30932310 (+)
C3H/HeJ	MGP_C3HHeJ_G0033211	protein coding gene	Chr8:32030816-32102372 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034015	protein coding gene	Chr8:33200962-33275483 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030964	protein coding gene	Chr8:27545967-27613919 (+)
CAST/EiJ	MGP_CASTEiJ_G0032538	protein coding gene	Chr8:31451826-31523165 (+)
CBA/J	MGP_CBAJ_G0033189	protein coding gene	Chr8:34508716-34582889 (+)
DBA/2J	MGP_DBA2J_G0033342	protein coding gene	Chr8:30725029-30793418 (+)
FVB/NJ	MGP_FVBNJ_G0033287	protein coding gene	Chr8:30383562-30454257 (+)
LP/J	MGP_LPJ_G0033432	protein coding gene	Chr8:31923294-31994377 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033329	protein coding gene	Chr8:34038649-34110762 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034034	protein coding gene	Chr8:31788331-31858283 (+)
PWK/PhJ	MGP_PWKPhJ_G0032250	protein coding gene	Chr8:30241322-30311146 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032081	protein coding gene	Chr8:31067405-31134726 (+)
WSB/EiJ	MGP_WSBEiJ_G0032654	protein coding gene	Chr8:31929186-31996386 (+)

Human Ortholog

TEX15, testis expressed 15, meiosis and synapsis associated

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TEX15, testis expressed 15, meiosis and synapsis associated
Synonyms

CT42, SPGF25
Links

HGNC:11738

NCBI Gene ID: 56154

UniProt: Q9BXT5
Chr Location

8p12; chr8:30831544-30913008 (-) GRCh38

MGI Vertebrate Homology

Tex15 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TEX15
Gene Tree

Tex15

Diseases

1 with human TEX15 associations

				Human Disease	Mouse Models
				spermatogenic failure 25 IDs spermatogenic failure 25 DOID:0111920 OMIM:617960

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
1 images
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

115 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice are infertile due to arrest of meiosis stemming from failure to repair double-strand breaks. However, female mice are fertile.

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All GO Annotations

24
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

14
cDNA Data

8
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tex15

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All Sequences

54
RefSeq

12
UniProt

4
CCDS

CCDS22232.1

Ensembl

ENSMUSG00000009628 (Evidence)
NCBI Gene

104271

			Length	Strain/Species	Flank
genomic	ENSMUSG00000009628	Ensembl Gene Model \| MGI Sequence Detail	68845	C57BL/6J	± kb
transcript	ENSMUST00000009772	Ensembl \| MGI Sequence Detail	8405	Not Applicable
polypeptide	ENSMUSP00000009772	Ensembl \| MGI Sequence Detail	2785	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016254 testis-expressed protein 15

(term hierarchy)
InterPro Domains

IPR022188 TASOR, DUF3715

IPR032765 Testis expressed sequence 15 domain

IPR026616 Testis-expressed sequence 15 protein

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All nucleic 10

cDNA 8

Primer pair 2

Microarray probesets 2

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MGI:1920914, MGI:2142653, MGI:2145745

Summaries

All 35

Developmental Gene Expression 8

Gene Ontology 5

Phenotypes 8
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:353355 Yao X, et al., BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing. FASEB J. 2024 Jan;38(1):e23361

TSS for Tex15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76815	Chr8:34006688-34006706 (+)	-69 bp
Tssr76816	Chr8:34006758-34006772 (+)	-1 bp
Tssr2540	Chr8:34007302-34007328 (+)	549 bp
Tssr76817	Chr8:34007334-34007353 (+)	578 bp
Tssr76818	Chr8:34026606-34026615 (+)	19,845 bp
Tssr76819	Chr8:34026630-34026649 (+)	19,874 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24