Ube2n MGI Mouse Gene Detail - MGI:1934835 - ubiquitin-conjugating enzyme E2N

Symbol

Ube2n
Name

ubiquitin-conjugating enzyme E2N
Synonyms

1500026J17Rik, UBC13

Feature Type

protein coding gene
IDs

MGI:1934835
NCBI Gene: 93765
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:95351024-95381520 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 49.41 cM
Mapping Data

2 experiments

SNPs within 2kb

716 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1934835	protein coding gene	Chr10:95351007-95381520 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017670	protein coding gene	Chr10:97081925-97130094 (+)
A/J	MGP_AJ_G0017649	protein coding gene	Chr10:93659690-93691442 (+)
AKR/J	MGP_AKRJ_G0017608	protein coding gene	Chr10:96340202-96374807 (+)
BALB/cJ	MGP_BALBcJ_G0017613	protein coding gene	Chr10:93932471-93963917 (+)
C3H/HeJ	MGP_C3HHeJ_G0017435	protein coding gene	Chr10:96333834-96364650 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018070	protein coding gene	Chr10:100291681-100323306 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015751	protein coding gene	Chr10:89216004-89248079 (+)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0017405	protein coding gene	Chr10:104430974-104463838 (+)
DBA/2J	MGP_DBA2J_G0017511	protein coding gene	Chr10:92751615-92782583 (+)
FVB/NJ	MGP_FVBNJ_G0017503	protein coding gene	Chr10:91999403-92034005 (+)
LP/J	MGP_LPJ_G0017585	protein coding gene	Chr10:97706178-97739385 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017533	protein coding gene	Chr10:105597773-105630936 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018106	protein coding gene	Chr10:96239542-96275755 (+)
PWK/PhJ	MGP_PWKPhJ_G0016782	protein coding gene	Chr10:92884393-92888795 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016570	protein coding gene	Chr10:95079320-95115170 (+)
WSB/EiJ	MGP_WSBEiJ_G0017059	protein coding gene	Chr10:96219721-96254652 (+)

Human Ortholog

UBE2N, ubiquitin conjugating enzyme E2 N

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBE2N, ubiquitin conjugating enzyme E2 N
Synonyms

HEL-S-71, UBC13, UbcH13, UbcH-ben, UBCHBEN, UBCHBEN; UBC13
Links

HGNC:12492

NCBI Gene ID: 7334

neXtProt AC: NX_P61088

UniProt: P61088
Chr Location

12q22; chr12:93405673-93441947 (-) GRCh38

MGI Vertebrate Homology

Ube2n stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: UBE2N
Gene Tree

Ube2n

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Phenotype Summary

24 phenotypes from 4 alleles in 3 genetic backgrounds
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

17
Targeted

3
Transposon induced

1
Genomic Mutations

2 involving Ube2n
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous disruption of this gene causes early embryonic lethality. Mice heterozygous for a gene trap allele show increased resistance to LPS-induced lethality while cultured immune cells display blunted LPS-inducible cytokine secretion and impaired activation of TRAF-mediated signal transduction.

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All GO Annotations

72
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

14
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ube2n

ZFIN ube2na, ube2nb

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All Sequences

52
RefSeq

4
UniProt

3
CCDS

CCDS48677.1

Ensembl

ENSMUSG00000074781 (Evidence)
NCBI Gene

93765

			Length	Strain/Species	Flank
genomic	93765	NCBI Gene Model \| MGI Sequence Detail	30497	C57BL/6J	± kb
transcript	NM_080560	RefSeq \| MGI Sequence Detail	3851	C57BL/6
polypeptide	P61089	UniProt \| EBI \| MGI Sequence Detail	152	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003289 ubiquitin-conjugating enzyme E2 N

(term hierarchy)
EC

2.3.2.23
InterPro Domains

IPR050113 Ubiquitin-conjugating enzyme

IPR023313 Ubiquitin-conjugating enzyme, active site

IPR000608 Ubiquitin-conjugating enzyme E2

IPR016135 Ubiquitin-conjugating enzyme/RWD-like
GlyGen

P61089 1 site, 1 O-linked glycan (1 site)

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All nucleic 14

cDNA 14

Microarray probesets 6

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MGI:2143895, MGI:2144921

Summaries

All 84

Developmental Gene Expression 1

Gene Ontology 15

Phenotypes 34
Earliest

J:214866 JACKSON BR, et al., Recurrent carcinoma of the rectum, surgical treatment. Calif Med. 1959 Sep;91:149-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ube2n:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95364	Chr10:95350732-95350750 (+)	-283 bp
Tssr95365	Chr10:95350824-95350832 (+)	-196 bp
Tssr95366	Chr10:95350978-95351023 (+)	-23 bp
Tssr95367	Chr10:95351032-95351042 (+)	13 bp
Tssr95368	Chr10:95359046-95359053 (+)	8,026 bp
Tssr95369	Chr10:95363028-95363031 (+)	12,006 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24