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Acox2 Gene Detail
Summary
  • Symbol
    Acox2
  • Name
    acyl-Coenzyme A oxidase 2, branched chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934852
    NCBI Gene: 93732
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:14210420-14244262 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 4.77 cM, cytoband A1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1041 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934852
 protein coding gene Chr14:14210406-14244262 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020991
 protein coding gene Chr14:567470-602342 (-)
A/J MGP_AJ_G0020939
 protein coding gene Chr14:540058-574051 (-)
AKR/J MGP_AKRJ_G0020916
 protein coding gene Chr14:546644-580487 (-)
BALB/cJ MGP_BALBcJ_G0020941
 protein coding gene Chr14:535460-569687 (-)
C3H/HeJ MGP_C3HHeJ_G0020726
 protein coding gene Chr14:555957-589574 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021375
 protein coding gene Chr14:576571-610276 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018944
 protein coding gene Chr14:1455416-1489744 (-)
CAST/EiJ MGP_CASTEiJ_G0020248
 protein coding gene Chr14:552305-592006 (-)
CBA/J MGP_CBAJ_G0020692
 protein coding gene Chr14:598752-632446 (-)
DBA/2J MGP_DBA2J_G0020815
 protein coding gene Chr14:522319-556215 (-)
FVB/NJ MGP_FVBNJ_G0020797
 protein coding gene Chr14:520466-555429 (-)
LP/J MGP_LPJ_G0020892
 protein coding gene Chr14:546947-584156 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020823
 protein coding gene Chr14:578541-613616 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021408
 protein coding gene Chr14:549768-584712 (-)
PWK/PhJ MGP_PWKPhJ_G0020000
 protein coding gene Chr14:549569-584291 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019821
 protein coding gene Chr14:558677-594510 (-)
WSB/EiJ MGP_WSBEiJ_G0020306
 protein coding gene Chr14:541965-576197 (-)



Homology
more
  • Human Ortholog
    ACOX2, acyl-CoA oxidase 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACOX2, acyl-CoA oxidase 2
  • Synonyms
    BCOX, BRCACOX, BRCOX, CBAS6, THCCox
  • Links
    NCBI Gene ID: 8309
    neXtProt AC: NX_Q99424
    UniProt: Q99424

  • Chr Location
    3p14.3; chr3:58505136-58537283 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ACOX2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
About 29% of mice homozygous for an endonuclease-mediated deletion spontaneously develop liver cancer at 8-9 months and exhibit liver inflammation and bile duct proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    55
  • cDNA Data
    44
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021751 Ensembl Gene Model | MGI Sequence Detail 33843 C57BL/6J ±  kb
    transcript ENSMUST00000164598 Ensembl | MGI Sequence Detail 2907 Not Applicable  
    polypeptide ENSMUSP00000126464 Ensembl | MGI Sequence Detail 681 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000003643 peroxisomal acyl-coenzyme A oxidase 2
      (term hierarchy)
    • EC
      1.17.99.3
    • InterPro Domains
      IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
      IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
      IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
      IPR012258 Acyl-CoA oxidase
      IPR002655 Acyl-CoA oxidase, C-terminal
      IPR046373 Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
      IPR029320 Acyl-coenzyme A oxidase, N-terminal
      IPR034171 Peroxisomal acyl-coenzyme A oxidase
    • GlyGen
      Q9QXD1 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 44
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:67589 Huyghe S, et al., Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse. Biochem J. 2001 Feb 1;353(Pt 3):673-80
    • Latest
      J:323193 Zhang Y, et al., Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice. Cell Death Dis. 2022 Mar 29;13(3):279
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory