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Lztfl1 Gene Detail
Summary
  • Symbol
    Lztfl1
  • Name
    leucine zipper transcription factor-like 1
  • Synonyms
    5530402H04Rik, 6130400H19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934860
    NCBI Gene: 93730
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:123523469-123546690 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 74.36 cM, cytoband F
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    600 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934860
 protein coding gene Chr9:123523469-123546762 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035482
 protein coding gene Chr9:126751413-126776428 (-)
A/J MGP_AJ_G0035463
 protein coding gene Chr9:121903053-121928200 (-)
AKR/J MGP_AKRJ_G0035396
 protein coding gene Chr9:125171435-125197798 (-)
BALB/cJ MGP_BALBcJ_G0035459
 protein coding gene Chr9:121836937-121861779 (-)
C3H/HeJ MGP_C3HHeJ_G0035166
 protein coding gene Chr9:125615059-125639873 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035982
 protein coding gene Chr9:130252570-130277299 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032864
 protein coding gene Chr9:119013895-119038090 (-)
CAST/EiJ MGP_CASTEiJ_G0034471
 protein coding gene Chr9:125642218-125682559 (-)
CBA/J MGP_CBAJ_G0035134
 protein coding gene Chr9:135002067-135037080 (-)
DBA/2J MGP_DBA2J_G0035293
 protein coding gene Chr9:121347256-121374242 (-)
FVB/NJ MGP_FVBNJ_G0035240
 protein coding gene Chr9:120249155-120272981 (-)
LP/J MGP_LPJ_G0035372
 protein coding gene Chr9:127154717-127177682 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035281
 protein coding gene Chr9:135811029-135844655 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036001
 protein coding gene Chr9:125630489-125656409 (-)
PWK/PhJ MGP_PWKPhJ_G0034175
 protein coding gene Chr9:121802552-121830778 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034012
 protein coding gene Chr9:125741782-125768398 (-)
WSB/EiJ MGP_WSBEiJ_G0034591
 protein coding gene Chr9:125474990-125498359 (-)



Homology
more
  • Human Ortholog
    LZTFL1, leucine zipper transcription factor like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LZTFL1, leucine zipper transcription factor like 1
  • Synonyms
    BBS17
  • Links
    NCBI Gene ID: 54585
    neXtProt AC: NX_Q9NQ48
    UniProt: Q9NQ48

  • Chr Location
    3p21.31; chr3:45823316-45916042 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lztfl1 mouse models; 1 with human LZTFL1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 5 alleles in 7 genetic backgrounds
    3 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit obesity, ventriculomegaly, decreased ERG a- and b-wave amplitudes, retinal degeneration, and reduced male fertility associated with decreased sperm number and sperm motility and abnormal sperm morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    14
  • cDNA Data
    20
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 93730 NCBI Gene Model | MGI Sequence Detail 23222 C57BL/6J ±  kb
    transcript NM_033322 RefSeq | MGI Sequence Detail 6689 ZRU/MplStud  
    polypeptide Q9JHQ5 UniProt | EBI | MGI Sequence Detail 299 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000010019 leucine zipper transcription factor-like protein 1
      (term hierarchy)
    • InterPro Domains
      IPR026157 Leucine zipper transcription factor-like protein 1
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 1
      cDNA 21
      Primer pair 1
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1921758, MGI:1921760, MGI:2143280, MGI:2147521
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:33331 Nishiguchi S, et al., A catalogue of genes in mouse embryonal carcinoma F9 cells identified with expressed sequence tags. J Biochem. 1996 Apr;119(4):749-67
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory