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Tcf23 Gene Detail
Summary
  • Symbol
    Tcf23
  • Name
    transcription factor 23
  • Synonyms
    2010002O16Rik, bHLHa24, Out
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934960
    NCBI Gene: 69852
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:31126006-31134362 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 16.90 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    395 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934960
 protein coding gene Chr5:31125946-31145406 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029404
 protein coding gene Chr5:28929393-28938117 (+)
A/J MGP_AJ_G0029370
 protein coding gene Chr5:27991443-27999843 (+)
AKR/J MGP_AKRJ_G0029321
 protein coding gene Chr5:29141958-29150325 (+)
BALB/cJ MGP_BALBcJ_G0029381
 protein coding gene Chr5:28510793-28519140 (+)
C3H/HeJ MGP_C3HHeJ_G0029102
 protein coding gene Chr5:29144341-29152691 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029834
 protein coding gene Chr5:30708427-30716783 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027072
 protein coding gene Chr5:25466902-25475276 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0029070
 protein coding gene Chr5:31278584-31286933 (+)
DBA/2J MGP_DBA2J_G0029219
 protein coding gene Chr5:28171382-28179740 (+)
FVB/NJ MGP_FVBNJ_G0029177
 protein coding gene Chr5:27586039-27594388 (+)
LP/J MGP_LPJ_G0029304
 protein coding gene Chr5:29391741-29400113 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029206
 protein coding gene Chr5:32176314-32184663 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029868
 protein coding gene Chr5:28645192-28653548 (+)
PWK/PhJ MGP_PWKPhJ_G0028237
 protein coding gene Chr5:27289450-27298297 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028067
 protein coding gene Chr5:28015031-28023390 (+)
WSB/EiJ MGP_WSBEiJ_G0028593
 protein coding gene Chr5:28708213-28716575 (+)



Homology
more
  • Human Ortholog
    TCF23, transcription factor 23
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCF23, transcription factor 23
  • Synonyms
    bHLHa24, OUT, TCF-23
  • Links
    NCBI Gene ID: 150921
    neXtProt AC: NX_Q7RTU1
    UniProt: Q7RTU1

  • Chr Location
    2p23.3; chr2:27149004-27156974 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female mice homozygous for a knock-out allele and older than 4 months of age show subfertility characterized by reduced gestational weight gain, decreased litter size, thin myometrium with a disorganized collagen matrix and discontinuous smooth muscle sheets, and impaired parturition with high rates of dystocia, resulting in significant fetal demise.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    876
  • Tissues
    147
  • cDNA Data
    12
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006642 Ensembl Gene Model | MGI Sequence Detail 8357 C57BL/6J ±  kb
    transcript ENSMUST00000006818 Ensembl | MGI Sequence Detail 4116 Not Applicable  
    polypeptide ENSMUSP00000006818 Ensembl | MGI Sequence Detail 209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917102
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 6
      Phenotypes 25
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:354446 Minisy FM, et al., Transcription Factor 23 is an Essential Determinant of Murine Term Parturition. Mol Cell Biol. 2024;44(8):316-333
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory