Mllt6 MGI Mouse Gene Detail - MGI:1935145 - myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6

Symbol

Mllt6
Name

myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
Synonyms

Af17

Feature Type

protein coding gene
IDs

MGI:1935145
NCBI Gene: 246198
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:97554240-97576289 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 61.05 cM
Mapping Data

2 experiments

SNPs within 2kb

480 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1935145	protein coding gene	Chr11:97553948-97576289 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019035	protein coding gene	Chr11:100117504-100141214 (+)
A/J	MGP_AJ_G0019003	protein coding gene	Chr11:95985627-96007528 (+)
AKR/J	MGP_AKRJ_G0018973	protein coding gene	Chr11:98965555-98987493 (+)
BALB/cJ	MGP_BALBcJ_G0018976	protein coding gene	Chr11:96458211-96508542 (+)
C3H/HeJ	MGP_C3HHeJ_G0018790	protein coding gene	Chr11:99080786-99106465 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019428	protein coding gene	Chr11:103203747-103231517 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017059	protein coding gene	Chr11:93440257-93462729 (+)
CAST/EiJ	MGP_CASTEiJ_G0018343	protein coding gene	Chr11:99935260-99975673 (+)
CBA/J	MGP_CBAJ_G0018761	protein coding gene	Chr11:107468696-107494599 (+)
DBA/2J	MGP_DBA2J_G0018869	protein coding gene	Chr11:95525035-95558747 (+)
FVB/NJ	MGP_FVBNJ_G0018858	protein coding gene	Chr11:95030596-95052855 (+)
LP/J	MGP_LPJ_G0018939	protein coding gene	Chr11:100616484-100644508 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018885	protein coding gene	Chr11:107309894-107334077 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019468	protein coding gene	Chr11:99266409-99290656 (+)
PWK/PhJ	MGP_PWKPhJ_G0018115	protein coding gene	Chr11:96515182-96544627 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017905	protein coding gene	Chr11:98986696-99008981 (+)
WSB/EiJ	MGP_WSBEiJ_G0018393	protein coding gene	Chr11:99160860-99197884 (+)

Human Ortholog

MLLT6, MLLT6, PHD finger containing

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MLLT6, MLLT6, PHD finger containing
Synonyms

AF17
Links

HGNC:7138

NCBI Gene ID: 4302

neXtProt AC: NX_P55198

UniProt: P55198
Chr Location

17q12; chr17:38705273-38729795 (+) GRCh38

MGI Vertebrate Homology

Mllt6 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MLLT6
Gene Tree

Mllt6

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

103
Endonuclease-mediated

2
Gene trapped

99
Targeted

2
Genomic Mutations

1 involving Mllt6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

142 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit no abnormal phenotype.

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All GO Annotations

14
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

872
Tissues

80
cDNA Data

92
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MLLT6

Xenbase mllt6

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All Sequences

56
RefSeq

10
UniProt

5
CCDS

CCDS25323.1

Ensembl

ENSMUSG00000038437 (Evidence)
NCBI Gene

246198

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038437	Ensembl Gene Model \| MGI Sequence Detail	22050	C57BL/6J	± kb
transcript	ENSMUST00000107586	Ensembl \| MGI Sequence Detail	7206	Not Applicable
polypeptide	ENSMUSP00000103212	Ensembl \| MGI Sequence Detail	1109	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR049781 AF-10/AF-17, PHD finger

IPR034732 Extended PHD (ePHD) domain

IPR050701 Histone Modification Regulator

IPR011011 Zinc finger, FYVE/PHD-type

IPR019787 Zinc finger, PHD-finger

IPR001965 Zinc finger, PHD-type

IPR019786 Zinc finger, PHD-type, conserved site

IPR013083 Zinc finger, RING/FYVE/PHD-type
GlyGen

B1AR10 1 site, 1 O-linked glycan (1 site)

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All nucleic 97

cDNA 92

Primer pair 3

Other 2

Microarray probesets 5

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MGI:2144108

Summaries

All 45

Developmental Gene Expression 5

Gene Ontology 3

Phenotypes 19
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mllt6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104644	Chr11:97552701-97552704 (+)	-1,537 bp
Tssr104645	Chr11:97553270-97553288 (+)	-961 bp
Tssr104646	Chr11:97553555-97553572 (+)	-676 bp
Tssr104647	Chr11:97553841-97553860 (+)	-389 bp
Tssr104648	Chr11:97553903-97553910 (+)	-333 bp
Tssr104649	Chr11:97553927-97553967 (+)	-293 bp
Tssr104650	Chr11:97554021-97554107 (+)	-176 bp
Tssr104651	Chr11:97554192-97554212 (+)	-38 bp
Tssr104652	Chr11:97573932-97573937 (+)	19,695 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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