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Arid1a Gene Detail
Summary
  • Symbol
    Arid1a
  • Name
    AT-rich interaction domain 1A
  • Synonyms
    1110030E03Rik, BAF250a, Osa1, Smarcf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1935147
    NCBI Gene: 93760
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:133406319-133484080 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.25 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1406 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1935147
 protein coding gene Chr4:133406319-133484682 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028904
 protein coding gene Chr4:135970028-136050653 (-)
A/J MGP_AJ_G0028863
 protein coding gene Chr4:130262572-130339780 (-)
AKR/J MGP_AKRJ_G0028815
 protein coding gene Chr4:133965896-134046095 (-)
BALB/cJ MGP_BALBcJ_G0028886
 protein coding gene Chr4:130901990-130979736 (-)
C3H/HeJ MGP_C3HHeJ_G0028600
 protein coding gene Chr4:134221328-134301845 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029328
 protein coding gene Chr4:140840528-140924164 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026599
 protein coding gene Chr4:123326256-123405519 (-)
CAST/EiJ MGP_CASTEiJ_G0028033
 protein coding gene Chr4:132325979-132418063 (-)
CBA/J MGP_CBAJ_G0028565
 protein coding gene Chr4:144543229-144633127 (-)
DBA/2J MGP_DBA2J_G0028714
 protein coding gene Chr4:130684405-130762217 (-)
FVB/NJ MGP_FVBNJ_G0028682
 protein coding gene Chr4:129576714-129655002 (-)
LP/J MGP_LPJ_G0028815
 protein coding gene Chr4:136073748-136153006 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028707
 protein coding gene Chr4:149022250-149103085 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029366
 protein coding gene Chr4:134387646-134468649 (-)
PWK/PhJ MGP_PWKPhJ_G0027753
 protein coding gene Chr4:127401275-127480003 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027579
 protein coding gene Chr4:130223302-130304577 (-)
WSB/EiJ MGP_WSBEiJ_G0028112
 protein coding gene Chr4:134575120-134650417 (-)



Homology
more
  • Human Ortholog
    ARID1A, AT-rich interaction domain 1A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARID1A, AT-rich interaction domain 1A
  • Synonyms
    B120, BAF250, BAF250a, BM029, C1orf4, CSS2, ELD, hELD, hOSA1, MRD14, OSA1, P270, SMARCF1
  • Links
    NCBI Gene ID: 8289
    neXtProt AC: NX_O14497
    UniProt: O14497

  • Chr Location
    1p36.11; chr1:26693236-26782104 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Arid1a mouse models; 10 with human ARID1A associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotypes from 5 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos with homozygous null alleles arrest development at E6.5 with failure to form a mesoderm layer. Mice homozygous for an allele lacking exon 2 and 3 die shortly after birth and exhibit an increase in the hematopoietic stem cell population of the fetal liver at E14.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1066
  • Tissues
    234
  • cDNA Data
    245
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000007880 Ensembl Gene Model | MGI Sequence Detail 77762 C57BL/6J ±  kb
    transcript ENSMUST00000145664 Ensembl | MGI Sequence Detail 8187 Not Applicable  
    polypeptide ENSMUSP00000122354 Ensembl | MGI Sequence Detail 2287 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000004262 AT-rich interactive domain-containing protein 1A
      (term hierarchy)
    • InterPro Domains
      IPR001606 ARID DNA-binding domain
      IPR036431 ARID DNA-binding domain superfamily
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR030094 AT-rich interactive domain-containing protein 1A, ARID/BRIGHT DNA binding domain
      IPR033388 SWI/SNF-like complex subunit BAF250, C-terminal
      IPR021906 SWI/SNF-like complex subunit BAF250/Osa
    • GlyGen
      A2BH40 7 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 254
      cDNA 246
      Primer pair 7
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915989
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 29
      Diseases 2
      Gene Ontology 30
      Phenotypes 77
    • Earliest
      J:320308 Valka I, et al., Separation and Quantification of Some Alkaloids from Fumaria parviflora by Capillary Isotachophoresis1. Planta Med. 1985 Aug;51(4):319-22
    • Latest
      J:352239 Du J, et al., ARID1A safeguards the canalization of the cell fate decision during osteoclastogenesis. Nat Commun. 2024 Jul 17;15(1):5994
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory